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the mechanisms of canonical Wnt pathway have been extensively studied, it is yet not understood how nuclear protein β-catenin can drive the wide arrays of transcriptional responses depending on the context
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identity and extracellular signaling, but how cell types, signaling mechanisms, and transcription factors jointly determine tissue structure is incompletely understood. The Koplev lab is recruiting
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focuses particularly on understanding how the tumor microenvironment (TME) undergoes architectural remodeling – including changes in extracellular matrix composition, tissue mechanics, and spatial
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