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generated by vaccines, understanding these responses is critical. Currently, the exact mechanisms underlying the activation of T cell responses against mRNA vaccines remain poorly understood. Key
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requires a simulator that captures malaria-specific recombination and transmission processes, generating realistic synthetic datasets while retaining sufficient computational eXiciency for large-scale
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drugs such as artemisinin, there is an urgent need to develop next generation drugs for malaria. Our laboratory has identified a novel host based phospholipase A2 enzyme, peroxiredoxin 6 (PRDX6-PLA2
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data from different groups of individuals with autism or neurodevelopmental disorders (R. Debré pediatric parisian hospital, n=1000) and controls from the general population (UK Biobank). She/he will
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probed by confocal microscopy. The project will then aim at devising a new generation LO chip model that better recapitulates the human lymphoid tissue architecture. We will use engineered stromal cells
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autism or neurodevelopmental disorders (NDD) and controls from the general population (UK Biobank, …). She/he will analyse the data with a focus on the interplay between the common and the rare variants
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of the tumor micro-environment including the onset of T cell exhaustion associated to chronic TCR signaling. CD4+ T cell help can potentially reactivate the generation of anti-tumor CD8+ effectors but
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an emphasis on tissue long lived cells such as stromal cells, and their crosstalk with tumor cells, immune cells and the vasculature. We perform mostly in vivo studies, combining lineage tracing and depletion