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analyze single-cell RNA sequencing (scRNA-seq) datasets using biostatistical and bioinformatics approaches. Conduct molecular, cellular, biochemical, and immunological analyses to support research
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program focused on understanding how RNA modifications regulate gene expression and cellular function in health and disease. Our laboratory investigates the molecular and biological functions of m6A
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presentation, HLA expression, interferon-response signaling, HER2, or tumor-intrinsic immune evasion. Experience with epigenetics, chromatin biology, transcriptomics, DNA methylation, ATAC-seq, RNA-seq, or other
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required: Functional genomics and pooled screening technologies CRISPR knockout, CRISPRa/i, or base-editing platforms NGS library preparation and sequencing methods, including: ATAC-seq CUT&RUN CUT&Tag RNA
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sequencing, and spatial transcriptomics. Be Bold. Qualifications: A PhD, MD, or MD/PhD in a biomedical sciences-related field is required, along with a peer-reviewed publication record. Experience in RNA
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catabolic and pain-related molecules, as well as cellular (cartilage and dorsal root ganglia explant cultures) and molecular (qPCR, RNA-seq) analyses. Generate data associated with the pharmacologic
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neurobiology, RNA biology, and evolution. We are especially interested in understanding: How does post-transcriptional control shape neural cell fate and disease? We have discovered canonical and non-canonical
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brain evolution. We employ a multifaceted strategy to bridge developmental neurobiology, RNA biology, and evolution. Learn more about our interests, motivations and discoveries: https://sites.duke.edu