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, functional and metabolic analyses, and co-culture models with tumour microenvironment cells. In vivo experiments using orthotopic mouse models will enable the study of their role in tumour formation and
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Supervisor: Dr Tim Halim Course start date: 1st October 2027 Project details For further information about the research group, please visit our website at https://www.cruk.cam.ac.uk/research-groups
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requires detailed imaging, beyond what is currently possible in humans in vivo. In an NWO-funded Vici project, we leverage Ultra-High Field MRI to bring the cerebellar mesoscale into view. In this PhD
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their website at https://www.naritalab.com/ Our laboratory investigates the biology of preneoplastic cell states, with particular interest in how changes in cell functional identity and plasticity are controlled
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of transplantable donor livers. Your main responsibilities - Performing (long-term) ex vivo liver perfusion experiments using hypothermic and normothermic machine perfusion platforms. - Evaluating mitochondrial
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-targeting AAV variants will subsequently be tested in a PMLD1 mouse model to determine their therapeutic potential in vivo. The project requires a strong foundation in neuroscience and an interest in both
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sample, and in vivo leukemia models Perform and oversee molecular, cellular, genomic, and functional assays Analyze, interpret, and integrate multi-omics datasets to generate biologically meaningful
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microscopy, electrophysiology, and in vivo models to address fundamental questions in neuronal and synaptic physiology and pathophysiology. The position provides an excellent opportunity to pursue a PhD
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elaborated at ICCVS. The first in vitro and in vivo studies are very encouraging, and the team plans to start clinical trials in a few years from a prospective perspective. More information at
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at https://biffilab.wordpress.com Pancreatic ductal adenocarcinoma (PDAC) remains a formidable clinical challenge. A major recent advance has been the development of KRAS inhibitors, which have shown