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, sudden death. Despite its high prevalence, the mechanisms driving disease onset and progression remain poorly understood, limiting effective treatment options. EIPH shares features with the human condition
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will investigate compounds targeting a specific signalling pathway to promote axon regeneration. Candidate compounds will be identified through computational screening and human-derived neuronal culture
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system and brain across the life course. Working with human samples and datasets, you will: Characterise relationships between gut microbiota, gut barrier function, systemic inflammation and peripheral
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to human gut organoids and primary airway epithelial cultures, to map innate immune responses and identify viral factors responsible for immune evasion. In parallel, you will develop a rapid RT-LAMP
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oxidative and nitrosative stress, and normalises BH4 redox balance. The PhD will first define how NOHA behaves as a ROS scavenger and NO donor in vitro and in primary human aortic endothelial cells. It will