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muscle fibres with human capillary endothelial cells and organ fat tissue from people with type 2 diabetes. We will identify new messengers within and between cells that impair glucose uptake, and thereby
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rapid cycle of protein synthesis and degradation represents a novel component that determines endothelial integrity. This project will follow up on these findings using a combination of molecular cell
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Alzheimer’s disease such as ApoE4. In this PhD project, you will apply this previous knowledge to develop cellular screening assays in order to identify novel candidate interventions for Alzheimer’s disease
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/02656736.2020.1852324 A team of physicists, biologists and clinicians will advise on the work performed by the student. The PhD student has a physics background and will create the novel form of advanced treatment
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this collaborative project, we will investigate the mechanisms of tRNA gene regulation using novel methods and technologies in human cells and budding yeast. We will take advantage of CRISPR-mediated approaches, high
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both prognostic and treatment effect modeling. You will have access to high quality clinical data to inspire and implements methods. You will finalize the research with a PhD thesis. Requirements
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, patients (and their loved ones) and other stakeholders, and translate new scientific insights into educational and other knowledge-sharing methods; You will actively participate in educational activities
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staff position within a Research Infrastructure? No Offer Description You will be investigating cytokine signaling pathways in macrophages, beyond the known JAK-STAT signaling pathways. Cytokines shape
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. Both labs have complementarity tools to tackle this novel hypothesis. The van Baarsen lab has access to unique human samples, and the van Egmond lab recently created novel mouse models. By studying
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imaging data. By extension, this project will help built a framework to determine the efficacy of (novel) drugs in individual lymphoma patients in a clinical interventional trial. Requirements Specific