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human iPSC derived retinal GACR models and perform tailored therapeutic screens with repurposed medicine taken from the parallel SYMPATHIC consortium (Karnebeek and coworkers 2023). The candidate will
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of type 2 diabetes In this project, we will study disrupted communication between fat tissue, capillaries and muscle cells as an early cause of type 2 diabetes. We will create human muscles in a dish from
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applicants for a PhD position in Stem cells and Multiple Sclerosis (MS). Your work will focus on human iPSC-based models of inflammation and MS to study microglial cell functioning in a white matter- and grey
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your findings in an array of cellular iPSC-models present in the lab, compare these to known iPSC- and human patient datasets and define a mechanism of action. You will then work with an (inter)national
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to disease models; Align these findings with human disease. Requirements Specific Requirements You have a master's degree in a field related to biomedical sciences, (medical) biology, biochemistry
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, 2024). We are seeking an enthusiastic candidate for one of the projects that is funded by ZonMW: Prof P.L. Hordijk - Innovative modelling of the human microcirculation by merging vascular cell biology
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these findings with human disease. Requirements Specific Requirements You have a master's degree in a field related to biomedical sciences, (medical) biology, biochemistry or bioinformatics; You have experience in
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this collaborative project, we will investigate the mechanisms of tRNA gene regulation using novel methods and technologies in human cells and budding yeast. We will take advantage of CRISPR-mediated approaches, high
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depressive symptoms, and these more often remain chronic than in younger populations. The relationship between mental health and daily functioning is complicated: functional decline is one of the causes
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. Both labs have complementarity tools to tackle this novel hypothesis. The van Baarsen lab has access to unique human samples, and the van Egmond lab recently created novel mouse models. By studying