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still not possible. To tackle this challenge, our teams combine complementary animal models: zebrafish, which display robust regeneration of the CNS after injury, and mice, which like humans do not. We
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including Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the second most common dementia. We use a combination of sophisticated mouse models and cutting-edge human stem cell and genome
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technologies to challenge human health problems. The Center translates its novel technologies and insights to widely applicable research tools, vaccines, diagnostics, and biopharmaceuticals. Our research pushes
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the investigation of cooperative interactions promoting human disease. To achieve this, we have taken a multi-faceted approach by combining mouse modelling with comprehensive CRISPR-based techniques and
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. The successful candidate will focus on the functional characterization of selected IBD candidate genes in enteroendocrine cells, Paneth cells, and/or T cells, using human primary cells and cell lines, gut
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to help us achieve following goals: to discover new therapeutic targets (using bulk/single cell multi-omics on surgical samples from human and mouse, performing bioinformatical analysis & biological