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of nucleotide metabolism across diverse human pathophysiological contexts. As a part of the newly established St. Jude Center for Pharmacogenomics, our laboratory aims to uncover fundamental mechanisms governing
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fundamental mechanisms by which primary cilia or mitochondria control cellular homeostasis and signaling are encouraged to apply. We use a broad range of approaches, including human pluripotent stem cells
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infected human cells, identify viral and host complexes in their native context, and combine this with structural modeling and proteomics to build a spatially and temporally resolved picture of the infection
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5.3 PFLOPS of power and 150 PB of storage capacity, link), a collaborative and supportive research environment, and the opportunity to work on high-impact problems in human health. St. Jude offers
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event and its role in cell transformation. The lab leverages genetically engineered mouse models, patient-derived xenografts, human and mouse tumor and primary cell lines as well as human induced
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tools to inform better therapies using human and genetic models. Key Responsibilities Design and conduct experiments investigating the mechanism of chimeric transcriptional factors in regulating gene
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molecular mechanisms by which endocytic structures remove damaged proteins in human physiology and neurodegenerative disorders. Successful candidates will have: A PhD in cell biology, neuroscience, or related
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to design and conduct experiments with mouse models and human T cells isolated from healthy donors. Besides, she or he will collaborate with other team members to analyze the results and present the findings
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responses to cancer therapies in human induced pluripotent stem cells) data for elucidating molecular mechanisms for health outcomes; and 3) evaluating health disparities through pharmacogenomics