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invested heavily in the development of new facilities, with our laboratories providing access to ultra-modern equipment and teaching facilities in areas such as biochemistry, biotechnology, cell and
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human spinal malformation for which Great Ormond Street Hospital is a national referral center (Maniou et al Development 2023). The successful candidate will be part of the Neurulation Biomechanics (Galea
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a biomechanical sensor and regulator of cardiac fibroblast proliferation, in the context of cardiac fibrosis. The project will involve using a wide range of molecular cell biology techniques, in
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, the mouse being one of the most used models. Nevertheless, animal alternatives such as advanced in vitro (e.g. cell cultures, organ on a chip methods) and in silico approaches (i.e. computational modelling
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the inclusion of a larger and wider range of biomarkers. These are key to ensuring treatments are appropriate for patients. One potential biomarker is given by the mechanical properties of cells and tissue
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biomechanics and cellular responses. Master advanced laboratory techniques, including cell culture, and work with a custom-designed mechanical rig. Make tangible contributions to a project with potential for