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Breaking the cell wall barrier to find new drugs for antimicrobial resistant fungi School of Medicine and Population Health PhD Research Project Competition Funded UK Students Dr Simon Johnston
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develop and may not be an option for all rare disease patients. Hence, there is a need for having a multi-pronged approach including drug repurposing to find novel therapies for rare neurodevelopmental
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, based at the Ludwig Institute in Oxford, a private Industry in Cancer Science AND Professor Fiona Ducotterd, head of drug discovery team at the Charity Alzheimer’s Research UK Drug Discovery Institute at
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eradicates disease, so patients face inevitable relapse. To find a cure for myeloma, new treatments that can target the remaining chemotherapy-resistant cells are needed. One reason myeloma is difficult
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of high throughput automated, quantitative drug screening (Sheffield Zebrafish Screening Unit). We have extensive experience of different drug screening assays using gene expression and fluorescence read
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Breaking the cell wall barrier to find new drugs for antimicrobial resistant fungi
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with their activity allowing us understanding of protein activity within their subsequent pathways. Targeting DUBs is emerging as a significant new drug discovery opportunity targeting chronic diseases
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binding sites on ligand affinity, which has skewed efforts towards nucleotide mimics. However, the lack of selectivity of nucleotide mimics is the Achilles heel of kinase drug discovery, because
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disease. It will also provide an efficient platform for therapeutic drug discovery. Zebrafish disease models have contributed to advances in understanding diverse human diseases. A secondary outcome from