23 drug-discovery PhD positions in United Kingdom

PhD Studentship: Development and Application of Enabling Methods for Drug Discovery

points for drug-discovery. However, methods to interrogate and manipulate PPIs are not well established. Moreover, intrinsically disordered regions – segments of protein with no fixed structure

PhD Studentship: Integrating computational physics-based simulation and machine learning with drug discovery pipelines

, equipment, and travel related to the project. Overview Machine learning aims to transform the drug discovery landscape through the prediction of potential new therapeutics with unprecedented speed and

PhD Studentship: Data-driven realisation of molecular editing for drug discovery

– [email protected] Project summary Drug discovery pipelines are driven by iterative cycles in which molecules are designed, synthesised, purified and tested.  A remarkably limited toolkit of reactions

PhD Studentship: AMR pathogens in cystic fibrosis: Development of host-relevant models and discovery of antibiotic combinations

for new drugs to treat AMR pathogens Pseudomonas aeruginosa and Mycobacterium abscessus in the lungs of cystic fibrosis (CF) patients. Mycobacterium abscessus is intrinsically resistant to many drugs

PhD Studentship - Extending the Chemical Space of mAb Based Cancer Treatment with DNA Nanostructures

immunology, investigating the synthesis and evaluation of a modular cancer therapy platform. We propose to develop DNA nanopores into a modular platform that allows them to act as a drug carrier to enhance

PhD Studentship: Cyclic peptide discovery for intracellular protein targets

challenges in peptide therapeutics discovery for intracellular targets lies in achieving reliable cell penetration. Unlike Lipinski’s 'rule of five' which can guide small molecule drug design, there is

PhD Studentship: Deep Learning of Reaction Barriers for High-throughput Retrosynthetic Drug Design

Supervisors: Prof. Reinhard J. Maurer, Prof. Scott Habershon Summary: The drug discovery pipeline involves the screening of many molecules before viable leads are identified. This involves screening

PhD Studentship: Cyclic Peptide Discovery for Intracellular Protein Targets

will be provided to contribute towards consumables, equipment, and travel related to the project. Overview One of the major challenges in peptide therapeutics discovery for intracellular targets lies in

Swansea University Research Excellence Scholarships (SURES): Fully Funded PhD Scholarship: The In Vivo Mechanistic Dissection of Lifespan Extension Pathways Using Senolytic Compounds in the African Turquoise Killifish Model of Ageing

life expectancy, it is extremely rare to grow old in good health and by the age of 85 essentially no individual is disease-free. As such, drug discovery research is focusing on potential interventions

PhD Studentship: AI and Graph Theory to Model Small Molecules: The Next Frontier in Chemical Space

or can be synthesized in the laboratory. Understanding the space is vital for natural product and drug discovery, but as yet only a tiny fraction of these so-called ‘small’ molecules has been fully