PhD Studentship - The Anti-cancer Potential and Pharmacological Characterisation of Frankincense Resin

Frankincense is a resin extracted from trees in the genus Boswellia and has been used as a traditional remedy for centuries. The pharmacologically active compounds are now known to be Boswellic acids which are of interest in modern medicine. For example, evidence shows that Boswellic acids can improve the symptoms of auto-immune diseases such as asthma and ulcerative colitis suggesting they exhibit anti-inflammatory properties. However, the full therapeutic potential of Boswellia remains underexplored.

For example, limited evidence suggested that Boswellic acids exhibit anti-cancer properties though the scope and mechanisms of action remained unclear. Furthermore, while there are many Boswellia species distributed throughout the world, the therapeutic potential of only certain examples had been explored. As such, it was likely that pharmacologically active compounds remained undiscovered.

To address this, our recently completed study provided a detailed characterisation of the anti-cancer potential, mechanisms of action and chemical profile of Boswellia carterii; a largely unexplored species. Key findings to date include:

Our research is at an exciting stage, but as our experiments to date have focussed on raw extracts (which contain a mixture of active and non-active compounds) more work is required to further elucidate the therapeutic potential of Boswellia species. As such, this fully industry funded iCASE studentship will take the project forward. Key objectives include:

The studentship is fully funded and includes:

• A fee waiver
• A stipend of £16,000.00 p.a. for three and a half years

The preferred candidate must have an exceptional understanding of human physiology, pathophysiology (including cancer biology) and cell biology. An understanding of analytical chemistry, in particular natural product isolation and purification is also highly desirable.

Candidates will hold a minimum of an upper 2nd class degree in a relevant subject area. Completion of a Masters degree in a relevant subject area is desirable but not essential. The project will utilise a range of advanced analytical techniques which may include HPLC, NMR, mass spectroscopy, PCR, western blot, flow cytometry, cancer cell migration and invasion assessment and photometric measurement of intracellular calcium dynamics, oxidative stress and mechanical function. While full training in all required techniques will be provided, the successful candidate will demonstrate they have considerable general laboratory and research experience.

Candidates are asked to provide a CV and personal statement outlining their suitability for this post. The personal statement should describe their background, skills, academic interests, and their motivation for doing a PhD in no more than 2 sides of A4. This should include evidence of satisfying the above requirements along with being able to work independently to a high standard, collaborate with others, and demonstrate excellent scientific writing skills.

Funding Eligibility: Only available to students with settled status in the UK.

Informal enquiries:[email protected]

Send CV and supporting statement to [email protected]