PhD Studentship – Sustainable Routes to High Value Scaffolds

Updated: about 12 hours ago
Location: Southampton, ENGLAND
Deadline: 31 Aug 2017


Highfield Campus

Closing Date:  

Thursday 31 August 2017



PhD Supervisor: Prof. Bruno Linclau

co supervisor: Prof. David Harrowven

PhD Description:

The project seeks to use thermochemical, photochemical and high pressure transformations in sequence to rapidly build and functionalise fluorinated 3D scaffolds.

The project draws on our experience in the synthesis of small fluorinated substrates, and in the investigation of how fluorination motifs modify their pharmaceutically relevant properties (hydrogen bond, acid/base, conformational and lipophilicity properties.  In addition, it brings in the expertise in high pressure chemistry of our collaborators at The University of Rouen, Profs. Isabelle Chataigner and Jacques Maddaluno.  Where appropriate, reaction sequencing and optimisation will be aided by the use flow chemistry techniques.  There will also be opportunities for exchange visit to France and the potential to work with industrialist on projects of mutual interest and benefit.  [See Linclau, B.; Wang, Z.; Compain, G.; Paumelle, V.; Fontenelle, C.Q.; Wells, W.; Weymouth-Wilson, A. Angew. Chem. Int. Ed. 2016,55, 674–678 (VIP).  and Graton, J.; Wang, Z.; Brossard, A.-M.; Goncalves Monteiro, D.; Le Questel, J.-Y.; Linclau, B. Angew. Chem. Int. Ed.2012, 51, 6176–6180 (VIP)].

The PhD is part of wider European Regional Development Fund sponsored collaboration, LabFact, that aims to strengthen Cross-Channel academic and industry partnerships in synthetic organic chemistry for the benefit of our region.  Its primary aim is to develop clean routes to fine chemicals and useful chemical scaffolds using sustainable techniques that minimise the use of chemical reagents (heat, light, electricity, high pressure etc.).

The project is funded for 3 years and welcomes applicants from the UK and EU who have or expect to obtain at least an upper second class degree in Chemistry or a closely allied subject.  Funding will cover fees and a stipend at current research council rates of £14,553 per annum.

Due to funding restrictions this position is only open to UK/EU applicants

Applications for a PhD in Chemistry should be submitted online at

Please ensure you select the academic session 2017-2018 in the academic year field and click on the Research radio button.  Enter Chemistry in the search text field.

Please place B. Linclau/D. Harrowven - LabFact in the field for proposed supervisor/project

General enquiries should be made to Prof. Bruno Linclau at .  Any queries on the application process should be made to

Applications will be considered in the order that they are received, and the position will be considered filled when a suitable candidate has been identified

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