PhD Studentship - Proteomic-based Characterisation of Tyrosine Kinase-targeted Therapies in Acute Leukaemia

Updated: over 2 years ago
Location: Newcastle upon Tyne, ENGLAND
Job Type: FullTime
Deadline: 15 Aug 2021

Value of award

100% of UK home fees paid.  Successful EU applicants will be considered for the Vice-Chancellor’s EU Research

Scholarship: www.ncl.ac.uk/postgraduate/funding/sources/internationalnoneustudents/vceupgr21.html

Number of awards: 1

Start date and duration: 20th September 2021.

Overview

Acute myeloid leukaemia (AML) is a malignant neoplasia from myeloid cells. Traditionally, AML treatment has been limited to intensive chemotherapy. Recently, protein kinases inhibitors (PKIs) have been developed as new drugs to disrupt the abnormal signal transduction in the therapy of AML.

In drug-target discovery, thermal proteome profiling (TPP) is used to measure the protein thermal stability in response to different drugs. In this project, TPP and full proteome analyses will be performed to investigate (off)-target effects, direct objectives, and downstream regulation of PKIs in AML.

Molecular targeted therapy and the development of PKIs has promising impact on AML patients. Multiple new types of PKIs have been selected to treat acute leukaemia patients separately or jointly with traditional treatments. However, there are still challenges to overcome, such as the off-target effects and stability of PKIs, mutations of protein kinases, best dose for individual patients, and drug-resistance for PKIs. Thus, screening new targets and seeking effective PKIs will provide more options for acute leukaemia treatment. In summary, this project will contribute to a better understanding of the molecular bases of the disease, and will improve its clinical management through the development of cutting-edge therapies.

Sponsor

Newcastle University

Name of supervisor(s)

Dr. JL Marin-Rubio , Dr. ME Dueñas and Professor M Trost.

Eligibility Criteria

Have or expect at least a 2:1 honours degree or international equivalent in Biochemistry, Molecular Medicine, Biosciences or similar. A further qualification such as an MSc or MRes is advantageous.

This award is available to Home and International (inc. EU) applicants.

To study this course you need to meet the following English Language requirements:

IELTS 6.5 overall (with a minimum of 5.5 in all other sub-skills).

How to apply

You must apply through the University’s online postgraduate application system. To do this please ‘Create a new account ’.

Only mandatory fields need to be completed. However, you will need to include the following information:

  • Insert the programme code 8300F* in the programme of study section
  • Select ‘PhD in the Faculty of Medical Sciences – Biosciences' as the programme of study
  • Insert the studentship code BI042 in the studentship/partnership reference field
  • Attach a covering letter and CV. The covering letter must state the title of the studentship, quote the studentship reference code BI042 and state how your interests and experience relate to the project
  • Attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualifications.

* The online application system will only allow one application using the programme code 8300F. If you are applying for TWO or more projects using that code then you will need to email our Postgraduate Admissions Service ([email protected] ) with the following information:

  • Your application number (from the first project application that you submitted online).

Contact

If you are interested in applying, send your CV and covering letter detailing your reasons for applying for this studentship to Dr. Marin-Rubio: [email protected] , Dr. Dueñas: [email protected] , Professor Trost: [email protected] .



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