PhD Studentship: Pancreatic beta cell glucolipotoxicity – how do dietary nutrients turn into toxins?

Applications are invited for a three-year PhD studentship inthe Mitochondrial Biology group of Dr Charles Affourtit, School of Biomedical Sciences, Faculty of Health. The studentship will start, 1 October 2024.

Director of Studies: Charles Affourtit ([email protected] )

2nd Supervisor: Natasha Hill ([email protected] )

3rd Supervisor: Gary Smerdon ([email protected] )

4th Supervisor: Lee Hutt ([email protected] )

Project Description

Type 2 diabetes is a pandemic disease that involves pancreatic dysfunction and has obesity as a major pathological risk factor. Bioenergetic failure plays an important role in the mechanism by which high sugar and fat levels compromise glucose-stimulated insulin secretion from pancreatic beta cells, but mechanistic understanding of this ‘glucolipotoxicity’ is incomplete. This PhD project will bridge various knowledge gaps by probing the energy metabolism of beta cells holistically under oxygen tensions that prevail in vivo. We expect to gain new insight in the behaviour of beta cells and their vulnerability to nutrient excess that will help improve the management of metabolic disease.

You will benefit from the support and expertise of an enthusiastic supervisory team as you develop skills in quantitative cellular bioenergetics, pancreatic islet biology and functional systems biology analysis, and you will apply an array of molecular and biochemical techniques. With laboratories on the city and hospital campuses of the University of Plymouth, and with direct input from DDRC Healthcare, the project has access to a broad range of specialised facilities. The supervisory team is diverse and offers ample scope to develop a strong professional network through collaboration and conference participation.

Eligibility

Applicants should have attained (or be predicted to attain this summer) a first- or upper-second-class honours degree in biochemistry, cellular and molecular biology or another relevant subject. A Master’s qualification or previous laboratory experience in these areas would be an advantage. Applicants should be able to demonstrate their motivation towards research, preferably showing an interest in metabolic health and cellular energy metabolism.

If your first language is not English, you will need to meet the minimum English requirements for the programme, IELTS Academic score of 6.5 (with no less than 5.5 in each component test area) or equivalent.

The studentship is supported for 3 years and includes full Home tuition fees plus a stipend of £18,110 per annum 2023/24 rates (2024/25 rates TBC) and will only fully fund those applicants with relevant qualifications who are eligible for Home fees.  Applicants normally required to cover International fees will have to cover the difference between the Home and the International tuition fee rates (approximately £13,244 per annum 2024/25 rate).

NB: The studentship is supported for three years of the four-year registration period.

The fourth year is a self-funded ‘writing-up’ year.

If you wish to discuss this project further informally, please contact Dr Charles Affourtit, [email protected] .

To apply for this position, please click the Apply button above.

Please ensure to clearly state the name of the studentship on the top of your personal statement.

Please see here for a list of supporting documents to upload with your application.

For more information on the admissions process generally, please visit our How to Apply for a Research Degree webpage.

The closing date for applications is 3pm (UK Time) on 9 May 2024.

Shortlisted candidates will be invited for interview before the end of May.