PhD Studentship - Mesenchymal Stromal Cells in Multiple Myeloma

Supervisor: Dr Andrea Mohr, University of Essex

Multiple myeloma (MM) is a cancer of the bone marrow. Due to significant improvements in treatment, the disease can be controlled for several years before the majority of cases relapse. Bone marrow mesenchymal stromal cells (MSCs) are regarded as important drivers of multiple myeloma  (MM) pathobiology. However, so far it remains undefined how MSCs cause changes in bone marrow immune cell populations and thereby contribute to disease progression. To characterise MSCs in MM, you will study MSCs from patients with different disease stages.

Training:

• Culture techniques of mesenchymal stromal cells
• Flow cytometry
• Cell imaging
• General molecular and cellular techniques
• Scientific writing
• Training though the University of Essex’ unique professional development scheme

Responsibilities and tasks:

• Plan and perform experiments, analyse data and contribute to the writing process of scientific papers.
• Keep up to date with the scientific literature
• Attend PhD classes and institutional seminars
• Presentations at conferences, seminars, workshops, etc.
• Liase with clinical partners at the NHS
• Write and defend a PhD thesis at the end of the study program

Qualifications:

• We are looking for a enthusiastic PhD student with a high 2.1 or 1st class degree in Biomedical Sciences or a related subject.
• Masters degree in Cancer Biology or a related subject (e.g. Molecular Medicine, Immunology or Haematology).
• Placement year during undergraduate studies is desirable.
• Laboratory hands-on experience in tissue culture techniques is desirable and experience with primary cells would be advantageous, but neither are compulsory.
• Strong communication skills that are compatible with doctoral-level requirements, i.e., writing academic papers and giving presentations in English
• Proficiency in several of the following methods: mammalian cell culture, protein and DNA gel electrophoresis, western blot, PCR, cloning, site-directed mutagenesis, and/or immunohistochemistry
• Ability to follow protocols and work independently
• Good organizational skills, ability to document and analyse experiments
• Ability to work in a team

Apply Information:

Please apply by sending a CV (including contact details of two academic referees) and a cover letter explaining your motivation and suitability for the PhD to Emma Revill [email protected] . If you have any questions please feel free to contact the PhD supervisor. 

Funding Information:

This is a 3 -year studentship fully funded by the East Suffolk and North Essex NHS Foundation Trust. The studentship covers Home fees, an annual stipend of £16,062 and research funding. The studentship is available from 1 October 2022.