- Closing Date
- Saturday, 31st July 2021
DEADLINE FOR APPLICATIONS: 12 Midnight GMT 31 July 2021
Supervisors: James Dixon (School of Pharmacy), with Scancell (SME)
Development of an intradermal or inhaled DNA vaccine for COVID-19 and beyond
Intradermal and inhaled delivery of nucleic acid vaccines could be clinically effective, safe and globally-deployable against multiple complex diseases. This project will aim to combine physical and peptide-based delivery systems to enhance the efficacy and application of such technologies to the COVID-19 vaccine (‘Covidity’) presently under-development by our consortium (funded by Innovate-UK). This PhD will formulate and test combined systems for skin and lung-focused vaccine delivery in ex vivo tissue models, then move to rodent models, examining virus neutralisation, T cell responses and protection in virally challenged animals. The platform technology optimised and demonstrated will have wide ranging impact on future applications of nucleic acid vaccine approaches (including DNA, mRNA and oligo-based methods). The PhD will also directly aid attempts to translate antibody and peptide-engineering knowhow to generate a rapidly deployable and safe immunisation system for multiple complex diseases.
Please email to discuss the project; this is vital for a successful application:
Details: Projects with an industry partner (iCASE projects) offer a unique opportunity to undertake translational research.
Minimum qualifications and experience to undertake a research degree are detailed in the QAA UK Quality for Higher Education. For some subject areas, there is also an expectation that an individual will have undertaken a Masters qualification before beginning a doctoral programme. Candidates should possess the relevant qualifications and/or experience to demonstrate a capability to undertake a doctorate, which will be assessed during the recruitment process. More details can be found on the MRC website
These studentships are available to UK nationals, EU nationals and international applicants. Full details on eligibility, including residence requirements can be found on the Full Eligibility Criteria or on the UKRI website
Applicants who are classed as an international student will receive a full award, to include a stipend and tuition fees at the home level. International applicants will receive a University of Nottingham International Scholarship to “top up” the home tuition fee rate to the relevant institution international fee rate for 3.5 years.
How to apply for iCASE projects: Please complete the iCASE 2021 Application form one and iCASE 2021 Application form two as well as the Equal opportunities form
You will need to ensure that your referees complete the iCASE Referee form 2021.
Completed applications to be submitted to BR-RA-DTP-Funding@exmail.nottingham.ac.uk BY 12 MIDNIGHT GMT 31 JULY 2021
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