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From Zebrafish Tales to Human Interventions: Unveiling Inflammatory Pathways via RNA Binding Proteins in Neutrophil Biology School of Medicine and Population Health PhD Research Project Competition
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Biomaterials Science, 1, Article 929006. https://doi.org/10.3389/fbiom.2022.929006 Wingham, J.R., Omran, M., Shepherd, J., Majewski C (2020). Effect of Steam Autoclaving on Laser Sintered Polyamide 12. Rapid
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to validate the process. We have funding to carry out RNA sequencing and make bespoke cancer vaccines. The candidate should have a keen interest in oncology, complex cancer models, and therapeutic interventions
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. You would mainly work with Prime Editing which is a highly precise genome editing technology that utilizes an RNA-programmable nickase fused with reverse transcriptase (RT) and a prime editing guide RNA
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-of-function (repeat-associated non-ATG (RAN) translation, RNA toxicity) mechanisms. To unravel the ways in which C9orf72 expansions cause disease it is crucial to understand the normal functions of the C9orf72
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. Our team uses single cell techniques including single cell RNA sequencing, metabolomics, full spectrum flow cytometry and immunofluorescence microscopy alongside molecular biology techniques
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From Zebrafish Tales to Human Interventions: Unveiling Inflammatory Pathways via RNA Binding Proteins in Neutrophil Biology
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functional studies to help classify variants will be used for example RNA sequencing on blood samples to confirm splicing defects. If genetic variants in potential novel disease genes are identified
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, the major vault protein (MVP), which accounts for >70% of the total particle mass. The remainder of the particle is formed by two other protein subunits, VPARP and TEP1, and a vault RNA (vtRNA). The
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expected by chance. Full bioinformatics training will be given. To confirm the pathogenicity of any identified variants, functional analysis will be undertaken. For example, rna-sequencing could be performed