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recent data have uncovered that tissue-specific properties cooperate with biochemical signals to influence the surveillance mechanisms of local immune cells, in a process involving nuclear mechanosensing
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mechanisms of AML initiation and maintenance (Stavropoulou et al. Cancer Cell, 2016; Lopez et al., Cancer Discovery, 2019, Forte et al., Cell Metabolism, 2020; Leonards et al., Nat Commun 2020, Piqué et al
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, maintenance and relapse of acute myeloid leukemia (AML). We use various models to dissect critical cellular and molecular mechanisms of AML initiation and maintenance (Stavropoulou et al. Cancer Cell, 2016
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-like tissue culture model The Hardt lab studies Salmonella diarrhea. We are interested in the molecular and cellular mechanisms that explain how the food-borne pathogen colonizes the gut, infects
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The Hardt lab studies Salmonella diarrhea. We are interested in the molecular and cellular mechanisms that explain how the food-borne pathogen colonizes the gut, infects the gut tissue and causes
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between nutrition, metabolism and the epigenome. The group uses a translational approach from in vitro systems and mice to humans combining next-generation sequencing, single-cell methodologies, genetics
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. Broad research objectives of the group are to promote food and drug safety by elucidating mechanisms of toxicity. Researchers work to define relationships between chemical structures, molecular initiating
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into the mechanisms underlying the repair of injured tissues after various types of insults. Topics/approaches may include analysis of (i) the heterogeneity of injured/healing tissues and the corresponding healing
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, CD8 T cell exhaustion represents a central limitation to current anti-cancer immunotherapies and strategies aiming at reversing this process are still lacking. By exploring the intimate mechanisms
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this process are still lacking. By exploring the intimate mechanisms regulating CD8 T cell exhaustion, our group aims to identify innovative opportunities to reverse this process and unleash the full potential