Methylmalonic aciduria is a rare but life-threatening metabolic disease usually presenting the newborn or childhood period. The aim of our research is to develop novel treatments for this devastating disease, which we are pursuing through patient studies, as well as animal and cell models. As the largest European diagnostic centre and largest Swiss treatment centre for methylmalonic aciduria, we have a direct connection to patients and the potential for rapid clinical translation. Our research team forms part of a dynamic metabolic group at the University Children's Hospital, in search of the understanding and treatment of Rare Diseases.
Our previous work has demonstrated a physical link between the disturbed metabolic pathway in methylmalonic aciduria and the Krebs (TCA) cycle. Your project will use genetic (e.g. CRISPR-Cas) and pharmacological manipulation of involved enzymes, along with multi-omics technologies (e.g. proteomics, metabolomics) and biochemical studies to investigate the interaction and inter-regulation of these pathways, in vitro and in cell models. The goal is to identify potential entry points for nutritional complementation-based strategies, which can be translated further into animal models and the clinic.
The highly motivated candidate will
- have already obtained a PhD in biochemistry, molecular biology, or a related field
- have a strong research track record
- have prior experience with cellular models
The successful candidate will ideally
- have experience with metabolically driven diseases (also incl. cancer, diabetes, etc)
- have an interest in rare disease and clinical translation
- be driven, goal- and team-oriented
What we offer
We offer a competitive employment package, as well as a supportive and highly collaborative working environment that fosters academic career development. Zurich is a major European research hub that also offers an exceptionally high quality of life.
Place of work
University Children's Hospital Zurich
Steinwiesstrasse 75, 8032 Zurich
Start of employment
Employment start date to be mutually agreed.
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