Postdoctoral position for the Development of Protease-Responsive Diagnostic Devices

Postdoctoral position for the Development of Protease-Responsive Diagnostic Devices

The Responsive Biomedical Systems Lab (RBSL) at the Department of Health Sciences and Technology (D-HEST) of ETH Zürich is searching for a Postdoctoral researcher to work on the development of Protease-Responsive Molecular Devices under the supervision of Prof. Simone Schürle-Finke. RBSL develops micro and nanoscale systems designed for applications including diagnostics, drug delivery, and therapy.

Proteases are an important class of enzymes, that represent approx. 10% of all current drug targets. They are critical actors in health and disease and can provide insights into the state and progression of inflammatory conditions, cancer, and other ailments. Detection of protease activity in real-time and at the point-of-care could serve as a powerful clinical tool to inform application, monitoring, and adjustment of treatments.

You will work in close collaboration with engineers, biologists, and clinician scientists to inform and support the development of different micro-and nanoagents for monitoring proteases. These agents contain custom-tailored peptide substrates and respond with detectable change of a magnetic or acoustic signal upon cleavage. Expanding upon a selection of target proteases, you will also perform a comprehensive proteomic study of patient samples to identify protease profiles and subsequently design suitable corresponding peptide. As one concrete clinical application, the project aims to lay the foundation for real-time in vivo assessment of inflammation in patients suffering from rheumatoid arthritis.

The position has a 100% pensum and is initially limited for 1 year with the possibility of prolongation.

You will join an international team of chemical engineers, material scientists, and biologists and will be presented with outstanding opportunities for professional and personal development.

ETH Zurich is a family-friendly employer with excellent working conditions. You can look forward to an exciting working environment, cultural diversity and attractive offers and benefits.

You should hold a PhD in biochemistry or molecular biology with demonstrated expertise in mass spectrometry-based proteomics. Candidates with a biomedical or interdisciplinary background and solid biochemistry/molecular biology knowledge are also encouraged to apply.

Ideally, you have prior experience with peptides, peptide chemistry, protein LC-MS and analysis of proteomic data. Some previous experience with enzymology, particularly proteolytic enzymes and detection of protease activity (e.g. with peptide substrates), especially in biological samples would be a strong asset. We are looking for a team player with passion for taking on new challenges. Excellent knowledge of standard laboratory techniques (molecular biology focus), scientific rigor, and excellent presentation skills round up the profile.

ETH Zurich is one of the world’s leading universities specialising in
science and technology. We are renowned for our excellent education,
cutting-edge fundamental research and direct transfer of new knowledge
into society. Over 30,000 people from more than 120 countries find our
university to be a place that promotes independent thinking and an
environment that inspires excellence. Located in the heart of Europe,
yet forging connections all over the world, we work together to
develop solutions for the global challenges of today and tomorrow.

We look forward to receiving your online application including the following documents:

• CV
• Complete study record
• Motivation letter
• 2 letters of recommendation or contacts for reference

We exclusively accept applications submitted through the ETH online application portal. Applications via email or postal services will not be considered. Applications will be considered on a rolling basis until the position is filled.

For specific questions about this position, please contact Daniela Ritter by email at [email protected] (no applications).