Postdoc position: Investigating mechanisms of brain aging through in vivo CRISPR screens

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100%, Basel, fixed-term

The Laboratory for Biological Engineering (Prof. Randall J Platt) at ETH Zurich in Basel develops genome engineering technologies and applies them to a range of fundamental and disease-focused areas (www.platt.ethz.ch ). To advance these efforts we are seeking a full-time postdocwith expertise in molecular and cellular biology, mouse models of neurodegeneration, viral vectors, and deep sequencing library preparation.

Job description

We are looking for a researcher to join our multidisciplinary team of scientists and work on a new collaborative project focused on gaining insight into the molecular mechanisms of brain aging and neurodegeneration through the use of in vivo CRISPR screens. The candidate will be passionate about science, technology, collaboration, communication, and translatable research.

Your profile

• The ideal candidate should have a Ph.D. or equivalent in Molecular and Cellular Biology, Biochemistry, Neuroscience, Molecular Medicine, or a related field.
• The candidate must have extensive experience working with a range of molecular and cellular methods, including standard molecular biology techniques (molecular cloning, RT-qPCR/ddPCR, western blot etc.), mouse handling and tail vein injection, tissue processing for DNA/RNA extraction, histology, and preparation of deep sequencing libraries for functional genomics experiments.
• Expertise with stereotaxic surgery or molecular and behavioral characterization of neurodegenerative mouse models are major advantages.
• Other valued skills include prior experience with mammalian cell culture, virus production, flow cytometry, or single-cell RNA-sequencing, and knowledge in bioinformatics, statistics, or programming.
• The candidate must have a strong track record and interest in collaboration with multi-disciplinary scientists.
• Mastery of oral and written English and the ability to communicate effectively in a highly interdisciplinary and international environment are required.

ETH Zurich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.

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