Post-Doctoral Fellow: Nanoformulation

Updated: 9 days ago

Your position

Nanomedicine-based formulations have been used to deliver a wide variety of active pharmaceutical ingredients over the past several decades. These 'nanoformulations' can favorably alter a small molecule's pharmacokinetic profile and decrease adverse side effects. These advances, however, have not been readily applied to the area of Enzyme Replacement Therapy (ERT). ERT is the primary treatment strategy for lysosomal storage diseases, which have an incidence rate of approximately 1 in every 5000 live births. Unfortunately, the majority of patients on ERT will develop anti-drug antibodies within three months. The replacement enzymes are also not able to address the CNS manifestations of the disease, due to their inability to cross the blood-brain-barrier. Within the NRSG, we are developing a series of novel nano-based delivery platforms, and assessing their ability to improve the enzyme's pharmacokinetic, biodistribution and efficacy profiles. The place of work is Basel.

Your profile

The candidate will be a scientist with a recent PhD or MD in a nano-related field (such as chemistry, pharmacology, cell biology, or medicine), and have relevant publications. The postdoctoral fellow will generate lipid-based formulations for ERT and then screen and evaluate these novel constructs under in vitro conditions. The candidate should be familiar with nanoparticle characterization methods, such as DLS and CAD/ELSD. Similarly, they should also be familiar with common techniques and assays in cell biology, such as tissue culture, enzyme kinetics, and fluorescence microscopy. This scientist will actively collaborate with colleagues in academia and industry in the fields of pharmacology and immunology. Fluency in English is required.

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