PhD student in Neuroscience Synapse Physiology of Learning and Memory

Updated: about 2 months ago

Our research group 'Cellular Neurophysiology' at the Department of Biomedicine is investigating functional properties of excitatory and inhibitory synapses onto young and mature neurons in the adult mouse hippocampus (Heigele et al. 2016, Nat Neurosci 19:263-270; Schulz et al 2018, Nat Commun, 39:5210-5221). In the new project, we will use cutting-edge electrophysiological, imaging and optogenetic techniques to focus on synaptic recruitment of adult born hippocampal neurons in vitro and in vivo. We will concentrate on network mechanisms underlying pattern separation, important for the distinction of similar memory items (see Lodge & Bischofberger 2019, Behav Brain Res 372:112036). We further want to use in vivo Ca2+-imaging (miniscope) to finally unravel the circuit mechanisms by which young neurons support pattern separation during learning behaviour.

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