Exploring the connection between lipogenesis and pheromone signaling in the model organism Caenorhabditis elegans.
The Laboratory for Bioanalytical Chemistry at the University of Neuchâtel (Switzerland) invites applications for a PhD research position at the interface of natural products chemistry, bioanalytical chemistry, chemical ecology, and biosynthetic studies.
Job description: The objective of the position is to perform and publish high quality research that explores pheromone biosynthesis in the model organism Caenorhabditis elegans, and ultimately earn a PhD in Chemistry. The successful candidate will work in close collaboration with another colleague and Prof. Stephan von Reuss. While the main focus of the position will be on research, the candidate will also participate in the supervision of practical laboratory courses for bachelor students at the Institute of Chemistry.
Project description: This project funded by the Swiss National Science Foundation (SNSF) will decipher the molecular and genetic basis of the biosynthetic steps that connect lipogenesis and ascaroside pheromone biosynthesis upstream of the canonical peroxisomal β-oxidation cycle in the model organism Caenorhabditis elegans. Using a combination of natural products isolation, structure elucidation, and total synthesis the candidate will identify biosynthetic intermediates that connect lipogenesis and ascaroside biosynthesis. Their orders of transformation as well as the underlying responsible genes will subsequently be characterized by analysis of mutant metabolomes and incorporation experiments with stable isotope labelled precursors.
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