Researcher position in the area of single-cell and transcriptomics and epigenomics.

Updated: about 2 months ago

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The position is based at unit of Molecular Neurobiology (MBB), at Karolinska Institutet, Stockholm, Sweden. The computational biologist position will be at the Castelo-Branco research group.

The Castelo-Branco research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. We are focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contribute to the transition between states within the oligodendrocyte lineage, with the aim to design epigenetic based-therapies to induce regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis. Our research group has performed single nuclei/cell RNA-Seq and identified several cell states within the oligodendrocyte lineage in development and disease (Science 2016, Dev Cell 2018, Nature Medicine 2018, Nature 2019). Our findings suggest that oligodendrocyte lineage cells might present other functional properties than previously thought.

Your mission
We have ongoing several projects with single-cell transcriptomics and epigenomics. The successful candidates will be integrated in a multidisciplinary team comprising computational, molecular and cellular biologists.

Your profile
We are looking for highly motivated, driven, inquisitive, enthusiastic persons interested in our area of research, and ready to explore new avenues in science. The candidates should have a collaborative approach to research, working productively in a team and contributing to a good social environment in the laboratory. The applicants must have a PhD degree in bioinformatics and computational biology or related, and strong programming skills (R and/or Python and/or others), UNIX and LINUX systems knowledge, familiarity with data science a big data. A strong track record in single cell omics in neurodegeneration, RNA splicing and chromatin regulation will be highly valuedA person is eligible to be appointed.

Researcher if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence, as well as documented research after the defense of his or her doctoral thesis.

Bases os assessment
We stress research expertise when assessing applicants.

What do we offer?
A creative and inspiring environment full of expertise and curiosity. Our research group is based at the Department of Medical Biochemistry and Biophysics (MBB), at the Karolinska Institutet (KI), Stockholm, Sweden, within the Unit of Molecular Neurobiology. The Unit of Molecular Neurobiology has presently seven research groups, focused on several aspects of development, stem cell biology, neuroscience and cancer, providing a unique critical mass and expertize, and vibrant scientific environment. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna, Biomedicum

Application
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

An employment application must contain the following documents in English:

  • A complete curriculum vitae, including date of PhD defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work (nor more than 4 pages)
  • A selected list of publications (no more than 2 pages)
  • A personal letter highlighting previous scientific accomplishments, technical expertize and why the candidate is interested in joining the host lab (no more than one page)
  • Verifications for crediting of illness, military service, work for labour unions or student organizations, parental leave or similar circumstances
  • Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application deadline)
  • Selection
    A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

    Karolinska Institutet uses the following bases of assessment:

    - Documented subject knowledge of relevance to the area of research
    - Analytical skill
    - Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

    Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

    Welcome to apply at the latest 2021-01-12

    Permanent position are initiated by a six months trial period.

    All applicants will be informed when the recruitment is completed.



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