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The Department of Cell and Molecular Biology (CMB, https://ki.se/en/cmb/department-of-cell-and-molecular-biology) is one of five departments conducting advanced experimental research under one roof in the new building of Biomedicum, Karolinska Institutet (https://ki.se), one of Europe's largest laboratories with ultramodern facilities. CMB is a department with a strong focus on basic science and conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology.
The successful applicant will join a smaller group currently comprising four members. The research team is physically located at the Biomedicum quarter 7A and share lab with four other groups working on different aspects of biology, including genomic integrity/DNA repair, cell cycle regulation, metabolism and protein ubiquitylation. The position is placed in the research group of Olle Sangfelt (https://ki.se/en/cmb/olle-sangfelts-group) and the projects are focused on investigating how ubiquitin ligases controls different regulatory pathways essential for cellular life, in particular cell cycle control, DNA repair and cell motility. The overall goal of the research is to translate basic scientific discoveries to cancer biology and development of novel treatment strategies.
The projects are centered around functional analysis of ubiquitin ligases in combination with interdisciplinary translational studies and involves collaborations with both national and international researchers. The postdoc will operate closely with the group leader to jointly develop and organize laboratory duties, including organizing meetings/courses, ordering of lab-related items, introduction of new employees to maintain a high standard of professionalism within research group. The postdoc will carry out independent laboratory research to functionally explore specific ubiquitin ligases regulating critical targets that directly influence cancer ¨driver¨ and ¨escape¨ programs. The postdoc will also aid in biomarker discovery through close collaboration with scientific partners in the field. One important aim of the research is to unravel mechanisms of drug resistance and specific vulnerabilities in cancer that can lead to the development novel therapeutic approaches.
The successful applicant will hold a PhD in Cell Biology, Molecular Biology or Biochemistry. We are seeking a highly motivated postdoc with extensive experience in functional characterization of proteins regulating DNA repair/checkpoints, cell cycle and cell motility. Applicants should be able to demonstrate a strong academic record, including publications in well-reputed scientific journals (including first authorships). Documented technological experience in microscopy, protein interaction/activity analysis/screens and regulated gene silencing/overexpression systems, good knowledge in written and spoken English is required. Experience from ubiquitin research, transcriptional regulation, bioinformatics and cancer genetics is an advantage. The candidate should appreciate problem solving and development of new technologies required to bring the project forward but also demonstrate an ability to complete projects within a defined time frame.
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.
The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.
Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.
An application must contain the following documents in English or Swedish:
- A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
- A complete list of publications
- A summary of current work (no more than one page)
The application is to be submitted on the Varbi recruitment system.
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