Postdoctoral researcher (1-2 positions) in neurodegenerative disease mechanisms with focus on Alzheimer disease therapy

Updated: 23 days ago

The Department of Neurobiology, Care Sciences and Society (NVS) conducts world leading research in aging, dementia, epidemiology and care sciences. This research extends from basic molecular and cell levels to clinical research and societal studies. NVS educates almost a third of KI students at basic and advanced levels. The Department has approximately 450 employees and a revenue 2019 of 497 million SEK. It comprises seven divisions, located at Campus Flemingsberg and Campus Solna.

The Division of Neurogeriatric consists of about 65 employees. The division conducts experimental and translational research related primarily to Alzheimer's disease and other neurodegenerative diseases, but also more general molecular mechanisms with biomedical relevance are studied, in BioClinicum, KI Campus Solna and Neo, KI Campus Flemingsberg.


Do you want to contribute to top quality medical research?
The project

The project aims to explore novel therapeutic concepts for Alzheimer disease (AD) based on regulation of function of molecular chaperones or other systems responsible for intracellular protein folding and degradation. The project involves studies of biological effects using human cells and AD-related mouse models.

We are looking for a postdoctor to join the project for one year with possibility of extension. The position will be located at the KI Campus Solna in BioClinicum.


Your mission

The position involves analysis of potential drugs that target processes relevant for AD and other neurodegenerative diseases. Specifically, the function of regulatory components and potential drugs will be assessed in cell lines and mouse models, which are related to AD. Alzheimer disease and other neurodegenerative diseases are associated with aggregation of certain proteins such as beta-amyloid and tau.

This project focuses on tau aggregation by development of small molecule ligands, targeting protein-protein interaction. We are also interested in connection between tau aggregation and insulin resistance. We combine structural biology techniques such as computer aided drug design, biochemical and biophysical methods to develop novel ligands as potential drug candidates for AD. We investigate biological effects of these molecules and validate them in proof-of-concept experiments. The duties include in silico drug design using virtual screening, hit-to-lead compound development, lead optimization, implementation of biochemical assays for compound screening, target characterization in vitro in cell models and in vivo in various AD-related mice models


Your profile

You are expected to have a strong drive to pursue experimental research and an ambitious and innovative attitude. The project is pursued in collaboration with other researchers why documented good collaborative skills are necessary. Good ability to speak and write English is a requirement.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.


What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Your career continues here


Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.


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