Postdoctoral position: RNA epitranscriptomics and Immune Cell Development

Updated: about 1 month ago
Job Type: FullTime
Deadline: 30 Jul 2020

*Job Description*
An exciting opportunity for a Postdoctoral Fellow is available within the RNA and Stem Cell Biology group of Dr. Cristian Bellodi at the Division of Molecular Hematology of the Lund Stem Cell Center, Lund University, Sweden. Our laboratory focuses new post-transcriptional facets of gene expression control in stem and cancer cell at a molecular, cellular and organismal level. We recently uncovered a critical role for RNA modifications in protein synthesis and stem cell function (Guzzi et al., Cell 2018) and exciting research opportunities to study the in vivo role of different RNA modifying enzymes are available. Successful candidate should have extensive experience with mouse genetics and cellular immunological techniques and be interested in the clinical application of basic science research toward understanding the mechanisms underlying hematological cancers associated with stem cell dysfunction.

*Project Goal*
The research goal is to unveil the molecular basis by which RNA modifications regulate normal and malignant hematopoiesis in vivo. The applicant will have access to unique genetic models in addition to a wide array of biochemical methods and state-of-the-art high-throughput sequencing approaches available in our laboratory. Specifically, the selected candidate will be expected to:

• Characterize the hematopoietic systems of novel transgenic models with an emphasis on lymphoid lineages
• Phenotypic and functional analysis of hematopoietic stem and progenitor cells
• Study the effects of RNA modification on the transcriptome and translatome of rare hematopoietic cell populations
• Improve established methods and/or develop new methods for isolation and in-depth single-cell molecular profiling

*About us*
Our laboratory provides a vibrant and international research environment consisting of postdocs, technical staff, PhD and master students that share a common interest in understanding how gene expression is post-transcriptional regulated in stem and cancer cells. Our laboratory is embedded within the Division of Molecular Hematology of the Lund Stem Cell Center (LSCC), an internationally ranked research center within the strategic areas of Stem Cell Biology and Regenerative Medicine at Lund University, Scandinavia’s largest institution for education and research. As a member of the LSCC, the candidate will have the possibility to access state-of-the-art core facilities and attend seminars and workshops by national and international speakers within key areas of hematopoiesis, stem cell and cancer biology.

*Essential Skills and Requirements*
We are looking for highly motivated basic and clinical researchers with a recent PhD (preferably less than 3 years) and proof of productive research. Candidates should have significant experience with mouse work (handling, breeding, surgery, dissection, transplantation), primary cell culture, immunostaining, advanced flow cytometry and molecular biology. Background in mammalian hematopoiesis, immunology and stem cell biology is highly preferred. Applicants are expected to work independently as well as collaborate within a team. Excellent verbal and written English communication skills are required.

*To Apply*
Applications including (1) cover letter, (2) short summaries of your research interests and major accomplishments, and (3) contact information of three professional references should be emailed to: .

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