Postdoctoral position in Structural Biology

Published: 2021-11-15

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has over 45,000 students, more than 7,000 employees and a turnover of around SEK 7 billion.

The Cell and Molecular Biology department at Uppsala University has a strong and international research and teaching environment and is organized in six major research programs; Computational Biology and Bioinformatics, Microbiology and Immunology, Molecular Biophysics, Molecular Evolution, Molecular Systems Biology, Structural Biology. In total the department has over 200 scientists, including 60 PhD students.

The position is with the research group of Anna Sundborger-Lunna in the ICM Program in Structural Biology, https://www.icm.uu.se/structural-biology/ . The Sundborger-Lunna lab uses a combination of molecular biology, biochemical and structural biology techniques, including cryo-electron microscopy, to study how membrane-remodeling proteins regulate critical cell death processes. Our goal is to understand the interplay between proteins and membrane lipids in the control of cell fate and neurodegeneration. Uppsala University recently installed a 200kV Glacios cryo-electron microscope with a Falcon III direct electron detector and another facility housing a 300kV Titan Krios equipped with a K3 detector with an energy filter is located nearby, at the SciLifeLab campus in Solna, less than 60 min from Uppsala: https://www.scilifelab.se/units/cryo-em/ .

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Duties
The research project is focused on the structural basis for amyloid protein misfolding and its implication in mitochondrial and cellular function, and a major component is cryo-EM analysis of protein assemblies (including sample preparation, cryo-EM analysis, image processing and model building.  

Requirements
To qualify for an employment as a postdoctoral fellow, you must have a PhD degree or a foreign degree equivalent to a PhD degree in Biochemistry, Biophysics, Structural Biology (or a related field). The PhD degree must have been obtained no more than three years prior to the application deadline. The three-year period can be extended due to circumstances such as sick leave, parental leave, duties in labor unions, etc.

Extensive experience in protein biochemistry and single-particle/helical cryo-EM analysis using standard image processing workflows is required. The applicant must have a good ability to work independently as well as in a group and be organized, creative, quality minded and decisive. Excellent written and oral knowledge of English is required, as the work takes place in an international environment.

Additional qualifications
Experience with cryo-tomography is preferred, but not required.

The application
Your application must include a personal letter where you describe yourself, your research interest, experiences and why you are interested in and suitable for the position (max 2 pages). A CV containing your education, other qualifications and a publication list. A copy of your PhD diploma and of your thesis (can be provided as a link). Contact information (E-mail and telephone) of two reference persons.

About the employment
The employment is a temporary position according to central collective agreement. Scope of employment 100 %. Starting date as soon as possible or as otherwise agreed. Placement: Uppsala.

For further information about the position, please contact: Anna Sundborger-Lunna, [email protected] , + 46 (0) 76 047 2807.

Please submit your application by November 30th 2021, UFV-PA 2021/4354.

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Submit your application through Uppsala University's recruitment system.

Placement: Department of Cell and Molecular Biology

Type of employment: Full time , Temporary position longer than 6 months

Pay: Fixed salary

Number of positions: 1

Working hours: 100%

Town: Uppsala

County: Uppsala län

Country: Sweden

Union representative: Seko Universitetsklubben [email protected]
ST/TCO [email protected]
Saco-rådet [email protected]

Number of reference: UFV-PA 2021/4354

Last application date: 2021-11-30

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