Postdoctoral position in RNA Drug Delivery

Updated: 7 months ago

Information about the project
RNA and other oligonucleotide drugs offer a wide range of opportunities to selectively target a large part of currently undruggable human genes and gene products, but the poor cellular uptake and functional delivery of these high molecular weight modalities remain a problem and an impeding factor towards their clinical success.
The research project, to which we are now seeking a highly motivated and skilled postdoctoral researcher, is part of FoRmulaEx, a Chalmers hosted research centre that, in collaboration with AstraZeneca as well as other academic and industrial partners, aims to address the RNA delivery problem through interdisciplinary research. The announced position is placed in Elin Esbjörner’s research group in the Biology and Biological Engineering department and focuses specifically on mechanistic studies of the cellular uptake of different lipid nanoparticle (LNP) formulations and exosome-based carriers for delivery of mRNA. The research project involves both systematic mechanistic studies of the efficacy of different delivery vehicles and method development towards the establishment of novel quantitative and multimodal fluorescence imaging tools to facilitate detailed studies of cellular uptake processes, intracellular trafficking, and endosomal escape events in single cells.

Major responsibilities
The main responsibility of the postdoctoral researcher is to perform research within Elin Esbjörner’s research group towards fulfilling goals and visions of the FoRmulaEx consortium. The research project is an interdisciplinary and collaborative effort and the postdoc will therefore work both independently and as part of a team consisting of both academic and industrial partners. The successful candidate will work live cell confocal fluorescence microscopy (including established and own-developed quantitative image analyses), flow cytometry methods, mammalian cell cultures and standard molecular biology. The position also includes supervision of undergraduates and PhD students.

Position summary
Full-time temporary employment. Funds for this position are available, in first instance, for 2 years.

The successful candidate holds, at the start of the position, a PhD degree in Biotechnology, biochemistry, cell biology or similar discipline. Experience in live cell confocal imaging as well as mammalian cell culture, including transfection, is mandatory. Experience of studying and manipulating endocytosis and advanced knowledge and understanding of fluorescence spectroscopy (including FRET) is a strong merit. The successful candidate is expected to have excellent collaboration skills, good ability to plan and perform research independently as well as in teams, proven capacity of supervising students, and excellent abilities to communicate in English, both orally and in writing.

Chalmers continuously strives to be an attractive employer. Equality and diversity are substantial foundations in all activities at Chalmers.

Our offer to you
Chalmers offers a cultivating and inspiring working environment in the dynamic city of Gothenburg .
Read more about working at Chalmers  and our benefits  for employees.

Application procedure
The application should be marked with Ref 20200023 and written in English. The application should be sent electronically and be attached as pdf-files, as below:

CV: (Please name the document as: CV, Family name, Ref. number) including:
• CV
• Other, for example previous employments, project managing experience, supervision qualifications and positions of trust
• Full list of publications
• Two references that we can contact

Personal letter: (Please name the document as: Personal letter, Family name, Ref. number) including:
Maximum 2 page personal letter where you:
• Introduce yourself,
• Describe your previous research and main academic achievements
• Describe your qualifications and interest for the specific project
• Describe your future goals and ambitions.

Other documents:
• Attested copies and transcripts of completed education, grades and other certificates, eg. TOEFL test results.

Please use the button at the foot of the page to reach the application form. The files may be compressed (zipped).

Application deadline: 12 February 2020

For questions, please contact:
Elin Esbjörner, Docent, Chemical Biology,
Phone: +46 31 772 5120

The Department of Biology and Biological Engineering
The Department was founded January 1 2015, and started off with high ambitions. The aim was to grow and become a leading center of innovation by combining the latest research in life sciences with biochemistry. And the department got off to flying start. In its first year, the numbers for publication, citation and external funding have been excellent.

The department consists of four divisions, each conducting outstanding research in the areas of industrial biotechnology, systems biology, chemical biology and food science. The overall goal is to help build a sustainable society and improve human health.

Nearly 200 people from 20 countries are currently working at the department. The working environment is characterized by respect, cooperation, responsibility, creativity and job satisfaction.

The Department of Biology and Biological Engineering has summarized its mission in four points:
• To be an attractive environment for top-level researchers in biological engineering
• To deliver top-level research results and innovative solutions for use in a sustainable society
• To offer excellent education that develops creative engineers and scientists
• To be a major contributor to international visibility of Chalmers

*** Chalmers declines to consider all offers of further announcement publishing or other types of support for the recruiting process in connection with this position. ***

Chalmers University of Technology conducts research and education in engineering sciences, architecture, technology-related mathematical sciences, natural and nautical sciences, working in close collaboration with industry and society. The strategy for scientific excellence focuses on our eight Areas of Advance; Building Futures, Energy, Information & Communication Technology, Life Science, Materials Science, Nanoscience & Nanotechnology, Production and Transport. The aim is to make an active contribution to a sustainable future using the basic sciences as a foundation and innovation and entrepreneurship as the central driving forces. Chalmers has around 11,000 students and 3,000 employees. New knowledge and improved technology have characterised Chalmers since its foundation in 1829, completely in accordance with the will of William Chalmers and his motto: Avancez!

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