Dept. of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
We are looking for a highly motivated and talented postdoctoral candidate to take the lead on exciting research projects in the lab of Professor Sten Eirik Jacobsen. The position and corresponding research projects are focused on regulation of normal and malignant hematopoiesis and hematopoietic stem cell biology.
About the research lab
The Jacobsen lab comprises an international collaborative team focused on understanding at the single cell level the cellular and molecular pathways governing the earliest fate decisions in normal hematopoiesis (Carrelha, J., et al., Nature 2018; Sanjuan-Pla, A., et al., Nature 2013; Luis, T.C., et al., Nat Immunol 2013; Boiers, C., et al., Cell Stem Cell 2013) and how these are dysregulated in hematologic malignancies (Booth, C.A.G., et al., Cancel Cell 2018; Giustacchini, A., et al., Nat Med 2017; Woll, P.S., et al., Cancel Cell 2014; Mead, A.J., et al., N Eng J Med 2012; Tehranchi, R., et al., N Eng J Med 2010). This is studied in mouse models, as well as in relevant patients. Key technologies applied towards these research questions include high-throughput DNA and RNA sequencing including single cell analysis, genetic fate-mapping using next-generation-sequencing technology, flow cytometry, mouse genetics and various in vitro and in vivo stem cell assays. The postholder will have the opportunity to lead projects focused on the analysis of single-cell RNA-seq data to understand heterogeneity of normal, pre-leukemic and leukemic hematopoietic stem and progenitor cells (e.g. see our recent paper in Nature Medicine [Giustacchini, A., et al., Nat Med 2017]), to model hematopoietic stem cell biology through single cell functional assays and genetic fate-mapping (e.g. see our recent paper in Nature [Carrelha, J., et al., Nature 2018]), as well as to model establishment and therapeutic targeting of leukemic stem cells through genetic mouse models and patient material (e.g. see our recent paper in Cancer Cell [Booth, C.A.G., et al., Cancer Cell 2018]).
Projects will be pursued in part at the Center for Hematology and Regenerative Medicine (HERM), and in part at the Department of Cell and Molecular Biology (CMB). The Jacobsen lab also have close interactions with other world leading research groups, and the recruited postdoctoral candidate will benefit from interactions in this highly collaborative network.
The postholder will take the lead, together with the group leader and collaborators, to actively pursue novel studies on cellular and molecular mechanisms that regulate normal and malignant hematopoietic stem cell biology. This is studied in mouse models, as well as in relevant hematopoietic material from normal healthy donors and leukemic patients. Key technologies applied towards these studies include advanced flow cytometry, mouse genetics, high-throughput DNA and RNA sequencing including single cell analysis, and various in vitro and in vivo assays. The postholder must enjoy team work and interact well with others, including other members of the lab, as well as collaborating scientists and clinicians. Good communication skills will also be required for data presentations and to represent the group at local or external conferences. Emphasis will be placed on personal suitability.
- PhD degree
- Strong track record as evidenced by one or more high impact publications in relevant research journals
- Training in international leading laboratories focused on studies of hematopoiesis and cancer biology
- Experience with advanced state-of-the art flow cytometry (>10 fluorescent parameters) to study normal and malignant hematopoiesis
- Experience with genetically modified mouse models to study hematopoiesis at different stages of ontogeny and model in vivo impact of drug-treatment on cancer cells
- Good knowledge of spoken and written English
- Excellent interpersonal and communication skills
- Demonstrate ability to organize, plan and document experimental bench-work
- Ability to stay on top of the relevant research field
- In vitro assays to study hematopoiesis
- Experience with genetic modification strategies, such as CRISPR
- Previous experience with mentoring junior PhD students
An employment application must contain the following documents in English or Swedish:
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