PhD student in the area Pharmacokinetic-Pharmacodynamic modelling - Antibiotics

Published: 2024-05-03

The Department of Pharmacy at Uppsala University has an interdisciplinary environment at the center of the pharmaceutical arena. With frontline research, first-rate education and extensive collaborations we constitute an important driving force in the development of our academic field. IFF has approximately 150 employees and a revenue of nearly 160 million SEK.In this inspiring environment our rich diversity of research groups, several of international prominence, develop and conduct work of great scientific importance. Among our core competences are computational modelling and simulations, PKPD, in vitro ADME models, advanced in vivo methods, development of biological medicines, as well as patient and societal aspects, from optimizing the use of drugs in individuals to societal pharmaceutical policies. Together, we form a unique cluster of academic competences within pharmaceutical science, playing a key role in shaping the future of pharmacy in both Sweden and globally.

More information www.farmaci.uu.se

Duties/Project: A doctoral position focusing on the characterization of pharmacokinetic-pharmacodynamic relationships for the translation of antibiotic effects from advanced preclinical experimental systems to patients is available in the research area pharmacokinetic-pharmacodynamics, specialization antibiotics, at the Department of Pharmacy.

Antibiotic resistance is rapidly increasing globally and improved methods are needed that can accelerate the development of new antibiotic therapies. The experimental models most commonly used today to study pharmacokinetic-pharmacodynamic relationships of antibiotics focuses on the bactericidal effect in the medium and ignore the impact on tissues and the impact of the immune system, i.e. the processes that affect the clinical picture of the infection. In vitro systems that can mimic the physiological processes are therefore under development. An important next step is to clarify how the information from these systems should be translated into appropriate dosing strategies in patients. Via pharmacokinetic-pharmacodynamic relationships, we have previously demonstrated the possibilities of integrating different types of experimental data into pharmacokinetic-pharmacodynamic models to predict dosage regimens. Through these new experimental systems, we expect the translational capacity to improve further.

The overall aim of the project is to develop mathematical models of value for translation of antibiotic effects of antibiotics in 3-dimensional cell models (including lung) in bacterial infections into clinical outcome variables. The project will involve close collaboration with a Swiss consortium consisting of experimentalists, drug developers and clinicians. The models will be developed based on antibiotics that are currently used clinically to subsequently be used to predict the outcome of new substances that are under development.

Requirements:

To meet the entry requirements for doctoral studies, you must

• hold a Master’s (second-cycle) degree in pharmaceutical sciences, biomedicine, medicine, or engineering, or alternatively a Master’s education in pharmaceutical modelling or in drug development,
• have completed at least 240 credits in higher education, with at least 60 credits at Master’s level including an independent project worth at least 15 credits, or
• have acquired substantially equivalent knowledge in some other way.

We attach great importance to personal suitability as well as motivation and experience in research in pharmacokinetic-pharmacodynamic characterization / pharmacometrics. Completed courses should include pharmacokinetics, physiology, pharmacology, modelling and programming (e.g. in R). Experience in research around antibiotic therapy and/or cell systems is valuable. Applicants must be able to express themselves well, both orally and in writing, in English. Furthermore, the applicant must have good cooperation skills and demonstrated skill in conducting a scientific project in a structured and methodical manner.

Further information about the research-level education, eligibility requirements, and admission regulations can be found at Doctoral studies . Applications will be ranked by the supervisors in consultation with the Department Research-level Education group. The committee for Research-level Education at the Disciplinary Domain of Medicine and Pharmacy will admit the PhD student. Salaries will follow local guidelines at Uppsala University. Rules governing PhD candidates are set out in the Higher Education Ordinance Chapter 5, §§ 1-7 and in Uppsala university's rules and guidelines Policies and Regulations at Uppsala University . The holders of PhD student position primarily devote their time to own research-level education. Other duties at the Department involving teaching and administrative tasks maybe included in the framework of the position (max 20%). The PhD program normally lasts for 4 years research, plus maximally one year of teaching.

Application: The application should include (i) a motivation letter with a brief description of the candidate and research interests as well as experiences in relation to the requirements and qualifications listed above, and the topics pharmacokinetics, pharmacodynamics, pharmacometrics, and anticancer treatment, (ii) the candidate’s CV, (iii) copies of diplomas and certificates, (iv) two recommendation letters (where at least one should preferably would be from a supervisor of the Master thesis) and (v) thesis, as well as other relevant documents that the applicant wish to refer to, such as proficiency in English.

About the employment
The employment is a temporary position according to the Higher Education Ordinance chapter 5 § 7. Scope of employment 100 %.Starting date 15 August 2024 or as agreed. Placement: Uppsala

For further information about the position, please contact: Professor Lena Friberg, [email protected] .

For questions around the employment, please contact Human resource coordinator Pernilla Larsson [email protected] .

Please submit your application by 20 May 2024, UFV-PA 2024/1550.

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Placement: Department of Pharmacy

Type of employment: Full time , Temporary position

Pay: Fixed salary

Number of positions: 1

Working hours: 100%

Town: Uppsala

County: Uppsala län

Country: Sweden

Union representative: ST/TCO [email protected]
Seko Universitetsklubben [email protected]
Saco-rådet [email protected]

Number of reference: UFV-PA 2024/1550

Last application date: 2024-05-20

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