PhD student in Medical Science

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We are looking for a PhD student in Medical Science.

Your work will entail the investigation of how Wnt signaling, a cell-to-cell communication pathway conserved across the animal kingdom, acts as master regulator of cell fate. While the mechanisms of canonical Wnt pathway have been extensively studied, it is yet not understood how nuclear protein β-catenin can drive the wide arrays of transcriptional responses depending on the context or developmental stage. You will investigate how the activation of Wnt signaling leads to promiscuous protein-protein interactions that, in a complex but deterministic manner, steer genomic function to regulate and fine-tune cell fate.

As a PhD student, you devote most of your time to doctoral studies and the research projects of which you are part. Your work may also include teaching or other departmental duties, up to a maximum of 20% of full-time.

You have graduated at Master’s level in molecular biology with focus in neuroscience or completed courses with a minimum of 240 credits, at least 60 of which must be in advanced courses. Alternatively, you have gained essentially corresponding knowledge in another way.

Among the required qualification, the applicant will possess experience with advanced cell culture systems, which must include work with forebrain organoids and intestinal organoids.

In addition, the candidate must have experience with the following technologies:

- CUT&RUN

- single-cell RNA-seq analysis

- qRT-PCR

- Zebrafish embryo xenografts

- Standard molecular biology techniques (e.g., DNA cloning)

Meritorious will be considered experience in:

- Microscopy-based imaging

- Immunohistochemistry

- In vitro neuronal differentiation.

You are a curiosity-drive person, fascinated by the complexity of biological systems and their ability to self-organize. You are also drawn to teaching and supervision of younger students, and to work in cooperation in an internationally-oriented research group.

Your application must contain a letter of intent describing how your qualification make you a good fit in the research group.

Moreover, a brief (2-page) scientific proposal must be attached in which you propose how to discover the mechanism of transduction and the evolutionary origin of Wnt Signalling using model organisms and/or organoids systems.

Division of Molecular Medicine and Virology , at the Department of Biomedical and Clinical Sciences , carries out research, undergraduate and postgraduate education within Medical Science.

In connection with your admission to the doctoral program, your employment as a PhD student is handled. More information about the doctoral studies at each faculty is available at Doctoral studies at Linköping University

The employment has a duration of four years’ full-time equivalent. You will initially be employed for a period of one year. The employment will subsequently be renewed for periods of maximum duration two years, depending on your progress through the study plan. The employment may be extended up to a maximum of five years, based on the amount of teaching and departmental duties you have carried out. Further extensions can be granted in special circumstances.

Starting date by agreement. 

The salary of PhD students is determined according to a locally negotiated salary progression.

More information about employment benefits at Linköping University is available here.

Information about union representatives, see Help for applicants .

Apply for the position by clicking the “Apply” button below. Your application must reach Linköping University no later than January 2nd, 2024. 

Applications and documents received after the date above will not be considered.

We welcome applicants with different backgrounds, experiences and perspectives - diversity enriches our work and helps us grow. Preserving everybody's equal value, rights and opportunities is a natural part of who we are. Read more about our work with: Equal opportunities .

We look forward to receiving your application!

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