PhD position in the project “Amyloids in Alzheimer’s disease and Protein Based Biomaterials”

Updated: 23 days ago

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including aging, Alzheimer, biomaterial, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, bioorganic chemistry, immunology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in Neo at Campus Flemingsberg, a biomedical research building, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

We are looking for a doctoral student in the research group of Assistant Prof. Axel Abelein and Prof. Jan Johansson. The research group studies protein misfolding and amyloid structures related to neurodegenerative diseases, in particular Alzheimer’s disease, and biomaterials, and has its working space in Neo, KI Campus South in Flemingsberg, at the Department of Biosciences and Nutrition. The group consists of one professor, two assistant professors, two senior scientists and four post-docs and PhD students.

https://ki.se/en/bionut/laboratory-for-protein-misfolding-and-assembly

The doctoral student project and the duties of the doctoral student

This PhD project concerns the characterization of the underlying mechanisms of amyloid formation with the aims (I) to better understand the molecular mechanisms of Alzheimer’s disease and to find potential therapeutic strategies using the BRICHOS domain and (II) to design and create new biomaterials based on a solubility tag derived from spider silk proteins in combination with designed amyloidogenic and metal-binding proteins.

The PhD student will perform major parts of the experimental work of this project and will plan the experiments, analyze the data and interpret the results.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  • have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  • have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  • have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*
  • Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

    *If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

    B) Specific eligibility requirement

    You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

    - Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

    Follow the instructions on the web page English language requirements for doctoral education.

    Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

    (A) and (B)can only be certified by the documentation requirement for doctoral education .

    Skills and personal qualities

    This project covers many areas, including gene cloning and mutagenesis, recombinant protein production and purification, protein aggregation and amyloid formation assays, molecular protein structure determination techniques and others. Suitable backgrounds include studies in protein biochemistry, biophysics, biotechnology, biomedicine, or similar topics. Experience in working with proteins associated with amyloid formation and in the experimental techniques used in the project is advantageous.

    The successful candidate is expected to have a strong drive to pursue research, be organized and structured and have an ambitious and innovative attitude. The project is cross-disciplinary and pursued in collaboration with other research groups, and hence good collaborative skills are necessary. Emphasis will be put on personal skills in the evaluation process. Very good ability to speak and write English is a requirement.

    Terms and conditions

    The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

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    Application process

    Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

    Your application must contain the following documents. We prefer that your application is written in English, but you can also apply in Swedish:

    - A personal letter and a curriculum vitae
    - Degree projects and previous publications, if any
    - Any other documentation showing the desirable skills and personal qualities described above
    - Documents certifying your general eligibility (see A above)
    - Documents certifying your specific eligibility (see B above)

    Selection

    A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

    Karolinska Institutet uses the following bases of assessment:

    - Documented subject knowledge of relevance to the area of research - Analytical skill - Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

    All applicants will be informed when the recruitment is completed.

    www.bionut.ki.se

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