Doktorand (PhD) in Clinical Genetics (PA2018/2989)

Updated: 6 months ago
Deadline: 23 Sep 2018

Lund University was founded in 1666 and is repeatedly ranked among the world’s top 100 universities. The University has 40 000 students and 7 400 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.

The Faculty of Medicine is a part of Lund University, and is responsible for education and research within medicine and healthcare. Our academic programs are closely linked with the healthcare system and are firmly anchored in the faculty’s strong research tradition. Our research spans a broad field within experimental preclinical research, near-patient clinical research and health sciences research. The Faculty of Medicine, with its 1,800 employees and 2,700 students in Lund and Malmö, is a knowledge-intensive meeting place for students, teachers and researchers from all over the world.

The Department of Laboratory Medicine is one of six departments at Lund University’s Faculty of Medicine. We conduct leading research, both broad and specialised, within the field of laboratory medicine, focusing on the onset of disease and how we can improve diagnostics and treatment for patients. Some of our strongest areas with world-class research deal with cancer, genetics and blood.

The Devision of Clinical Genetics is doing an exiting project (Functional characterization of gene fusions in soft tissue tumors) within the field of experimental cancer research. Soft tissue tumors constitute a heterogeneous and clinically diverse group of neoplasms. Several subtypes are characterized by specific gene fusions that are crucial for tumorigenesis. Functional analysis of these gene fusions will provide important information on the pathogenetic mechanisms.

The PhD project will focus on functional evaluation of gene fusions in in vitro systems. Of particular interest are assays involving chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq) to identify target genes for chimeric transcription factors. Also other molecular and molecular cytogenetic techniques, notably single nucleotide polymorphism (SNP) arrays as well as bioinformatic analysis of sequencing data will be required.

Work duties
- Take part in the laboratory work and develop methods connected to the project
- Write articles and publications together with the supervisors
- Take part in everyday laboratory planning and meetings as well as participate in journal clubs, workshops, seminars and conferences
- Some administrative duties may occur
- Some teaching may occur
- Take part in the doctoral courses provided by the department and the faculty

Work with experimental animals is not included


The applicant must be a highly ambitious and motivated individual. The applicant's prior level of education should be within the field of molecular biology, and the applicant should have knowledge and documented experience in tumor genetics, and SNP array and ChIP-Seq analyses. Basic knowledge of LINUX and the statistic environment R is also qualifying. The applicant should be fluent in English.

Qualifying merits
Prior experience of analyzing cytogenetic and molecylargenetic data is a qualifying merit.

Emphasis will be held on personal suitability. 

Students with basic eligibility for third-cycle studies are those who- have completed a second-cycle degree- have completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or- have acquired largely equivalent knowledge in some other way, in Sweden or abroad.

The employment of doctoral students is regulated in the Swedish Code of Statues 1998: 80. Only those who are or have been admitted to PhD-studies may be appointed to doctoral studentships. When an appointment to a doctoral studentship is made, the ability of the student to benefit from PhD-studies shall primarily be taken into account. In addition to devoting themselves to their studies, those appointed to doctoral studentships may be required to work with educational tasks, research and administration, in accordance with specific regulations in the ordinance.

Type of employment
Limit of tenure, four years according to HF 5 kap 7§.

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