Doctoral student in Medical Science - B cell responses in antiviral immunity

Updated: 7 days ago
Job Type: Permanent
Deadline: 09 Dec 2019

The Department of Microbiology and Immunology is located at the Institute of Biomedicine at the Faculty of Health Care Sciences at Sahlgrenska Academy, University of Gothenburg. Research at the Department is conducted within microbiology and immunology, particularly at mucosal surfaces, and includes preclinical as well as clinical studies. The main research focus includes studies of the mechanisms of disease and immunity during various mucosal infections, vaccine research, adjuvant development and gastrointestinal disorders such as inflammatory bowel disease and colon cancer. Research in hematopoiesis, cellular ageing and protein quality control are also carried out at the department. Research is performed in close collaboration with Sahlgrenska University Hospital as well as research labs in Sweden, Europe, North and South America, Asia and Australia.

Project title: Effect of pre-existing humoral immunity on memory responses to influenza A virus


Job assignments

The PhD education in Medical Science comprise carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://medarbetarportalen.gu.se/sahlgrenskaakademin/forskarutbildning/languageId=100001

Project: B cell and antibody responses are key components of our defence against viral pathogens. Viruses are complex organisms with several surface proteins and each of them has several potential B cell targets. Memory responses are immune responses elicited after infection that allow rapid clearance of virus upon reinfection. Memory B cells and pre-existing antibodies are crucial in shaping our immune responses after repeated infection. However, the role of memory B cells and antibodies specificities in reshaping secondary immune responses is still unclear.

The main research conducted within this ERC-funded PhD project will be focused on the effect of epitope-specific memory B cells and antibodies during re-infection. In detail the PhD student will use in vivo infection and immunizations to generate and isolate epitope-specific memory B cells and antibodies. Further, extensive in vitro characterization using several immunological techniques (flow cytometry, ELISA, ELISPOT and more) will be performed. Isolated cells will be then transferred in vivo in defined combinations and the mice re-challenged by infection and immunization and their immune response followed. The work will also involve study of viral adaptation in vivo and in vitro. Overall the project will clarify the role of epitope specificity, of memory immune components, during secondary infection and immunization.

Third-cycle studies are equivalent to four year full-time and lead to a Degree of Doctor. Those appointed to doctoral studentships shall primarily devote themselves to their studies. Those appointed to doctoral studentships may, however, work to a limited extent with educational tasks, research and administration (departmental duties). Before a PhD degree has been awarded, duties of this kind may not comprise more than 20 per cent of a full-time post.


Eligibility

To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

A person meets the general entry requirements for third-cycle studies if he or she:
1. has been awarded a second-cycle qualification
2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or
3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad

A person meets the specific entry requirements for third-cycle studies in Medical Science if he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies


Assessment

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:
- specific knowledge and skills within the subject area and related research fields
- experience of scientific theory and relevant research methodology
- scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.


Employment

After admission to third-cycle studies you will be appointed to doctoral studentship. Regulations for employment of doctoral students are given in SFS 1993:100. The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. A person may be appointed to a doctoral studentship for a total of eight years. The total employment period may, however, not exceed the time corresponding to full-time third-cycle study for four years.

Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Microbiology and Immunology. Extent: 100%. First day of employment: as agreed.

Salaries for doctoral students are regulated in a local agreement at the University. 


For further information regarding the position

For more information about the project please contact the principal supervisor,
Davide Angeletti, Institute of Biomedicine, e-mail: davide.angeletti@gu.se 


Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives


How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

You must include the following, in pdf format

  • Personal letter
  • CV
  • Diploma and transcripts showing that you meet with the general entry requirement
  • Proof of completion of  English 6 course or the acquired equivalent knowledge through previous studies

If your degree is from a university outside of Sweden, check what you need to submit at https://www.universityadmissions.se/en/All-you-need-to-know1/Applying-for-studies/Documenting-your-eligibility-for-studies/Instructions-for-Masters-applicants/Specific-requirements-for-my-country1/ where you can also see what you need to submit in order to fulfill the English language requirement.

  • If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.

Closing date: 2019-12-09

The University of Gothenburg promotes equal opportunities, equality and diversity.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.


The University of Gothenburg tackles society’s challenges with diverse knowledge. 47 500 students and 6 400 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.


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