Doctoral (PhD) position in chemical and genetic screens related to cancer therapies

Updated: about 2 months ago

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Cancer Therapy Group lead by Prof. Oscar Fernández-Capetillo is integrated at the "Genome Biology" Division, together with other competitive groups that work in areas such as DNA repair, epigenetics, advanced imaging or next generation genomics and is located at SciLifeLab, Solna.

Research in the group focuses on phenotypic screenings aiming to find genes or chemicals that can be of help in fighting against age-related diseases currently lacking a cure. This approach allows the identification of biologically relevant molecules at physiological conditions, and the current projects involve exploiting replication stress as anti-cancer strategy, cancer immunotherapy and amyotrophic lateral sclerosis. At SciLifeLab, our team is surrounded by other world leaders in various biomedical research areas, and has access to national facilities for proteomics, microscopy, next generation sequencing, chemical biology, drug discovery and development, among others.

The doctoral student project and the duties of the doctoral student

We are currently looking for a PhD student to join our team. The student will be responsible for his / her own project and should be able to work well within a team of research group members and collaborators. The student should, with the guidance from the supervisor(s), be able to plan and perform experiments, analyse results, write scientific articles, and present results at scientific meetings.

The project is aimed to define identify new mechanisms of resistance to cancer therapies including immunotherapy, as well as novel mutations and/or biomarkers that can predict the sensitivity to these therapies. To this end, we will combine genetic and chemical screens, which will be followed by cellular and molecular biology experiments aiming to understand the mechanistic basis of our discoveries. Ultimately, the projects main aim is to better identify the patients that are going to benefit the most from various cancer therapies as well as to improve their efficacy.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  • have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  • have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  • have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*
  • Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

    *If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

    B) Specific eligibility requirement

    You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

    - Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

    Follow the instructions on the web page English language requirements for doctoral education.

    Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

    (A) and (B)can only be certified by the documentation requirement for doctoral education .

    Skills and personal qualities

    We are seeking highly motivated and enthusiastic candidates with education in Cell Biology, Molecular Biology or other relevant fields. Experience and expertise in cell and molecular biology, is highly desired. In addition, knowledge in high-throughput imaging or screening technologies, while not a must, would be appreciated. In addition, knowledge in immunology would be valued. Complete fluency in both written and spoken English is a request, and good communication skills will be valued. Successful candidates should have strong organizational skills with the ability to work within a collaborative team. The candidate’s personal skills will be highly valued.

    Terms and conditions

    The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

    Application process

    Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

    Your application must contain the following documents:

    - A personal letter and a curriculum vitae
    - Degree projects and previous publications, if any
    - Any other documentation showing the desirable skills and personal qualities described above
    - Documents certifying your general eligibility (see A above)
    - Documents certifying your specific eligibility (see B above)


    A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

    Karolinska Institutet uses the following bases of assessment:

    - Documented subject knowledge of relevance to the area of research
    - Analytical skill
    - Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

    All applicants will be informed when the recruitment is completed.

    More information about the research group:

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