VAC_10_2024_Phd Student_Leukemia and immuno-oncology

Josep Carreras Leukaemia Research Institute (IJC), Spain

Updated: 2 months ago
Job Type: FullTime
Deadline: 26 Feb 2024

19 Feb 2024
Job Information
Organisation/Company

Josep Carreras Leukaemia Research Institute (IJC)
Research Field

Medical sciences » Cancer research
Researcher Profile

First Stage Researcher (R1)
Country

Spain
Application Deadline

26 Feb 2024 - 12:00 (Europe/Madrid)
Type of Contract

Temporary
Job Status

Full-time
Hours Per Week

39
Offer Starting Date

1 Apr 2024
Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The Josep Carreras Leukaemia Research Institute (IJC) is a non-profit research institute based in Barcelona dedicated to advancing the understanding of leukemia and related disorders, in collaboration with the University of Barcelona and the Autonomous University of Barcelona. The IJC has laboratories in 5 clinical campuses: i) Hospital Clínic, ii) Hospital de Sant Pau and iii) Hospital Germans Trias Pujol iv) Hospital del Mar and v) Hospital Josep Trueta Girona. IJC serves as a collaborative center for basic researchers and physicians to work together on fundamental clinical and biological aspects of leukemia. The IJC offers an excellent work environment based on a multidisciplinary fusion of state-of-the-art ideas and facilities.

For further information, please, visit our webpage: http://www.carrerasresearch.org/en  and the Josep Carreras nonprofit organization: https://www.fcarreras.org/en .

Leukemia and immuno-oncology research group, led by Dr Laura Belver, is looking for a motivated PhD student. 

This contract is part of the project: Development of cell-based therapies targeting DNA-reactive B cells in SLE, funded by Lupus Research Alliance (Award ID: 1143347). 

Research Description

The standard of care for SLE has been traditionally based on the use of non-specific anti-inflammatory and immunomodulatory/immunosuppressive agents. Although these therapies significantly improve disease symptoms, they are associated with a broad range of short- and long- term adverse effects and their efficacy remains suboptimal in controlling lupus-related flares. This speaks to the urgent need of developing new therapeutic interventions that target specific molecular mechanisms involved in the pathogenesis of the disease and provide higher efficiency and safety for SLE treatment.

The goal of this project is to create innovative therapies based on chimeric T-cell receptors, specifically engineered to target pathogenic autoantibody-producing B cells in SLE while preserving non-autoreactive counterparts.

For more information, visit our lab websites: https://www.carrerasresearch.org/en/research/leukemia-and-immuno-oncology

https://belverlab.org/

Main responsibilities

The candidate person will perform tasks for the development of an experimental therapeutics research program focused on SLE. These tasks will include the implementation of experimental methods in molecular biology and biochemistry, the execution of in vitro assays using both established cell lines and primary cells, and the use of specialized analytical systems such as flow cytometry. In addition, the candidate will perform procedures with experimental animals and coordinate the management of murine colonies.


Requirements
Research Field
Medical sciences » Cancer research
Education Level
Master Degree or equivalent

Skills/Qualifications
General skills
  • A high level of motivation and interest in biomedical research.
  • Good communication skills.
  • Fluent in English

Technical skills

  • FELASA certification to work with experimental animals and expertise on mouse work.
  • Experience in tissue culture (cell lines and primary cells), and molecular biology and biochemistry techniques.
  • Experience in immunology-related projects will be positively considered.

    Languages
    ENGLISH
    Level
    Excellent

    Research Field
    Medical sciences » Cancer research
    Years of Research Experience
    None

    Additional Information
    Benefits

    The Leukemia and Immuno-Oncology group is a young and vibrant research team compound of international and multidisciplinary scientists. Our work focuses on the study of different hematologic malignancies and autoimmune disorders by implementing our knowledge in different fields, including cell and molecular biology, biochemistry, bioinformatics and experimental therapeutics. By combining basic and translational research, we provide a broad perspective on specific clinical challenges that range from the characterization of central molecular mechanisms involved in the pathogenesis of the diseases that we study, to the application of that knowledge to the development of new therapeutic strategies for their treatment.

    What we offer

    • Be part of a young, collaborative, and international work environment with cutting-edge technologies and interdisciplinary teams of scientists, including experts in medicine, immunology, genomics, and bioinformatics.
    • An exciting and innovative research project.
    • The stimulating environment of the Barcelona metropolitan area.
    • 1-year contract
    • Career Development Plan

    Work Location(s)
    Number of offers available
    1
    Company/Institute
    IJC Can Ruti
    Country
    Spain
    State/Province
    Barcelona
    City
    Badalona
    Geofield


    Where to apply
    Website

    https://institut-josep-carreras-ijc.jobs.personio.com/job/1422632?_pc=1242413#a…

    Contact
    State/Province

    BARCELONA
    City

    Badalona
    Website

    http://www.carrerasresearch.org/en
    Street

    Ctra de Can Ruti, Camí de les Escoles s/n
    Postal Code

    08916

    STATUS: EXPIRED

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