The Centre for Genomic Regulation (CRG) is an international research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG shares principles of an interdisciplinary, motivated and creative scientific team that is supported by high-end and innovative technologies and a flexible and efficient administration.
In November 2013, the CRG received the 'HR Excellence in Research' logo from the European Commission. This is in recognition of the institute's commitment to developing an HR Strategy for Researchers designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers .
We are looking for a postdoctoral researcher to join the “Evolutionary Processes Modeling” group to help elucidate cancer mutational processes using cell culture experiments and computational analysis of the resulting data.
Cancer is a genetic disease, subject to population genetics forces like mutation, selection and stochasticity. Our lab has recently demonstrated that the sequence context of somatic mutations can aid in the identification of genes that drive cancer as well as genes that the tumor cannot afford to lose (www.biorxiv.org/content/10.1101/485292v1 , www.nature.com/articles/ng.3987 ). In addition to genes, we have also identified cancer driver loci in the non-coding part of the genome (www.nature.com/articles/s41467-017-00100-x ).
Our lab is particularly interested in how the evolution and survival of cancer cell populations relies on mutation influx and selection pressures. To this end, we develop mathematical and computational approaches to estimate mutation rates and selection. We use whole-exome sequencing and whole-genome data repositories to analyze selection on coding and non-coding sequences. We now want to enlarge the scope by investigating specific cancer mutational processes in data from cancer cell culture experiments. The results will inform mutational null models necessary for the estimation of selection. Estimates of the strength of selection in cancer allow for a prioritization of genes and non-coding regions by their disease relevance, with the ultimate goal of promoting therapeutic advances.
The Evolutionary Processes Modeling lab was established in October 2018 and is part of the “Bioinformatics and Genomics” program at the CRG in Barcelona, Spain. Further information can be found at www.crg.eu/en/programmes-groups/weghorn-lab .
Whom would we like to hire?
- PhD degree in biology or a related discipline.
- Proficiency in cell culture experiments using certain cancer cell lines.
- Familiarity with computational analysis of sequencing and other biological datasets.
- You are highly motivated and eager to work on biological problems through the use of a combination of experimental (cell culture) and computational approaches.
The Offer – Working Conditions
- Contract duration: until the end of the project.
- Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
- Target start date: Immediately.
We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section .
We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.
The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.
Applications should be addressed to Dr. Donate Weghorn and include:
Applications should be submitted online through the "Apply" button below. Enquiries can be addressed to firstname.lastname@example.org .
All personal data requested by CRG from applicants will be treated in accordance with the principles of the Data Protection Act (15/13 December 1999).
- Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.
- Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.
- Offer Letter: Once the successful candidate is identified the Human Resources department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.
Deadline: October 15, 2019.
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