Postdoctoral Position in Molecular basis of muscle aging (# of pos: 2)

We seek for a highly competitive postdoctoral fellow to study skeletal muscle aging. We are looking for highly motivated and ambitious experimental biologists, with a strong background in bioinformatics, to join our research team in the Department of Experimental and Health Sciences of the Pompeu Fabra University (UPF) at the PRBB, in Barcelona.

We seek for a highly competitive postdoctoral fellow to study skeletal muscle aging. We are looking for highly motivated and ambitious experimental biologists, with a strong background in bioinformatics, to join our research team in the Department of Experimental and Health Sciences of the Pompeu Fabra University (UPF) at the PRBB, in Barcelona. We study the mechanisms underlying tissue regenerative decline with aging, and in particular the mechanisms controlling muscle aging (sarcopenia), with the aim of preventing or delaying sarcopenia through rejuvenating strategies. You will be employed on a three-years project, and your work will combine transcriptomics, epigenetics, bioinformatics and computational biology, with mouse genetics, to define the intricate regulatory circuitry of muscle aging and potential rejuvenating strategies Recent publications from the lab
• García-Prat L, Perdiguero E, Alonso-Martín S, Dell’Orso S, Ravichandran K, Brooks SR, Juan AH, Campanario S, Jiang K, Hong X, Ortet L, Moiseeva V, Rebollo E, Sun H-W, Musarò A, Sandri M, del Sol A, Sartorelli V, Muñoz-Cánoves P. FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age. Nature Cell Biol, 2020
• Segalés J, Perdiguero R, Serrano AL, Sousa-Victor P, Ortet L, Jardi M, Budanov A, Garcia-Prat L, Sandri M, David M. Thomson DM, Karin M, Lee JH, Muñoz-Cánoves P. Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals. Nature Commun, 2020
• Solanas G, Peixoto FO, Perdiguero E, Jardí M, Ruiz-Bonilla V, Datta D, Symeonidi A, Welz PS, Caballero JM, Sassone-Corsi P, Muñoz-Cánoves P*, Benitah SA*. Aged stem cells reprogram their daily rhythmic functions to adapt to stress. Cell, 2017
• Autophagy maintains stemness by preventing senescence. García-Prat L, Martínez-Vicente M, Perdiguero E, Ortet L, Rodríguez-Ubreva J, Rebollo E, Ruiz-Bonilla V, Gutarra S, Ballestar E, Serrano AL, Sandri M, Muñoz-Cánoves P. Nature 529:37-42, 2016
• Geriatric muscle stem cells switch reversible quiescence into senescence. Sousa-Victor P, Gutarra S, García-Prat L, Rodriguez-Ubreva J, Ortet L, Ruiz-Bonilla V, Jardí M, Ballestar E, González S, Serrano AL, Perdiguero E, Muñoz-Cánoves P. Nature 506:316-21, 2014