Postdoctoral position at the Gene Function Lab

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

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The role

A postdoctoral research position is available in Dr. de la Luna’s laboratory to carry out a research project on DYRK kinases as regulators of transcription. We have shown that one of the DYRK family members, DYRK1A, is recruited to promoter regions of a subset of genes where it acts as a CTD-kinase (Mol Cell, 57: 506-520, 2015, doi:10.1016/j.molcel.2014.12.026). The project aims to explore whether other members of the DYRK family are able to perform this role and if so, identify commonalities/differences with DYRK1A’s activity.

About the lab

The lab works on a family of protein kinases known as DYRK (dual-specificity tyrosine-regulated kinases), whose members -DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4- participate in the regulation of processes critical for cell viability and homeostasis. In general, alterations in DYRKs (expression or mutation) are linked to different cancer types. In addition, mutations in several DYRK genes are associated to developmental disorders, as in the case of the DYRK1A haploinsufficiency syndrome or the DYRK1B-associated metabolic syndrome. The group aims to dissect how DYRK activities are linked to human pathology. We are particularly interested on the DYRK-associated activities that impact on the regulation of expression programs either directly on chromatin or indirectly through modulation of signaling pathways. Publications of the group include Gut, 68:1465-1476, 2019. [doi:10.1136/gutjnl-2018-316128]; Cell Rep, 23:1867-1878, 2018. [doi:10.1016/j.celrep.2018.04.008]; Mol Cell, 57: 506-520, 2015. [doi:10.1016/j.molcel.2014.12.026]