POSTDOCTORAL CANDIDATE TO APPLY FOR A FELLOWSHIP IN NEURODEGENERATION

Cell-specific transcriptomics regulation in brain diseases

We are looking for a very motivated talented postdoctoral researcher to apply for a 2 year postdoctoral fellowship of the Ministerio de Universidades Maria de Zambrano Program at Universitat Autònoma de Barcelona.

More information (pages 19-21): https://agr.uab.cat/docs/MD_PortalAjuts/Convocatoria_Next-Gen._DEF_SIGNA...

The candidate will join the ¨Neurobiology of Alzheimer’s disease¨ lab leaded by Prof. Carlos A. Saura at Institute of Neuroscience (INc)-UAB (https://inc.uab.cat/en; Barcelona, Spain). http://www.sauralab.com/ 

Dr. Saura’s lab is currently focused on understanding how brain functions during memory processing and the cellular and molecular mechanisms involved in brain dysfunction, memory loss and neurodegeneration in age-related cognitive disorders. Our lab combines molecular approaches and cutting-edge genomic, transcriptomic and proteomic methodologies to better understand the molecular pathways causing neuronal dysfunction, memory loss and neurodegeneration in Alzheimer’s disease.

To study cell-specific transcriptional mechanisms involved in synaptic function and memory processing and how they are altered in Alzheimer’s disease, we recently generated mutant mice expressing Tag transcripts in neuronal-specific populations. We apply neurobiology, behavioral, transcriptomics and systems biology analyses to understand the transcriptional pathways underlying neurodegeneration and memory loss in Alzheimer’s disease mouse models.

Tasks

The research project is aimed to identify cell-specific transcriptional changes in vulnerable neuronal circuits associated with synaptic dysfunction and memory loss in Alzheimer’s disease. The candidate will conduct experimental analysis (neurophysiological, pathological, behavioral…), and bioinformatics and systems biology of gene profiles in our novel cell-specific Alzheimer’s disease mice, which will be then integrated with published gene expression datasets from human brain. We expect that these cell-specific translational analysis will reveal novel disease-associated genes and pathways useful for identifying potential novel biomarkers and therapeutic targets for Alzheimer’s disease. So, we are looking for a highly motivated and strong postdoctoral candidate with experience in transcriptomics, bioinformatics, systems biology and/or neurobiology.