PhD STUDENT - EPIGENETIC CONTROL OF HAEMATOPOIESIS

The Josep Carreras Leukaemia Research Institute (IJC) is a nonprofit research institute based in Barcelona and dedicated to advancing our understanding about leukaemia and related disorders, in partnership with the University of Barcelona and University Autònoma of Barcelona. The IJC has laboratories in three clinical campuses: i) Clinic Hospital, ii) Sant Pau Hospital and iii) Germans Trias i Pujol Hospital. IJC serves as a collaborative hub for basic investigators and physicians to work together on fundamental biological and clinical aspects of leukaemia. The IJC offers an excellent work environment built around a multi-disciplinary fusion of ideas and state-of-the-art facilities.

The Josep Carreras Leukaemia Research Institute Can Ruti is looking for a Research Assistant to provide scientific support to the Epigenetic Control of Hematopoiesis group lead by Dr. Jose Luis Sardina.

Research Description

Epigenetic Control of Haematopoiesis Group is working to uncover the molecular mechanisms governing blood cell fate decisions, with a special interest in those leading to the onset of clonal haematopoiesis and myeloid malignancies (AML, MDS, CMML…) during ageing. To address this goal, they are combining transcriptome (by RNA-seq) and epigenomic profiling (by WG(ox)BS-seq, ATAC-seq and ChIP-seq for histone marks) in human and mouse primary blood samples with in-depth molecular studies (by CRISPR/Cas9 (epi)genome editing) in unique cellular models of experimentally induced blood cell fate conversions.

Please also visit our group webpage:

http://www.carrerasresearch.org/en/epigenetic-control-of-haematopoiesis_129594

What we need

• Master title (or equivalent) in Biomedical Sciences.
• Competitive academic record to apply for local/European scholarships.
• A high level of motivation and interest.
• Fluent in English.

Skills Specifications

• Previous research experience in: 
• Basic molecular biology: Cloning, nucleic acid isolation, PCR, Western blot.
• Epigenetics/Genomics: Chromatin and DNA immunoprecipitation (ChIP/DiP).
• Cell biology: Cell culture, primary cell isolation, transfection, infection, immunofluorescence, Flow Cytometry…
• Animal work: Accreditation required.
• Advanced level in data analysis (Excel, R, Phyton…).
• Excellent communication and organizational skills.

What we offer 

• 3-years predoctoral position.
•  Incorporation in a multinational and highly collaborative team.
• An exciting and innovative research project.
• Working in the mixed basic and clinical research environment of the Josep Carreras Leukaemia Research Institute.
• The stimulating environment of the Barcelona metropolitan area.
• Incorporation Q4 2021

How to apply

To apply for this opportunity, please send your resume and a cover letter and (incl. the contact details of two referees) to[email protected]  including the reference PHD_JS_53.

Deadline for Applications

Please submit your application by July 30th, 2021.