PhD student – analysis of neuronal RNA modifications using LC-MS/MS

Updated: 2 months ago
Job Type: FullTime
Deadline: 05 Sep 2022

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research ' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

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The role

We are seeking an highly motivated PhD student, ideally with mixed/hybrid background in Molecular Biology (wet lab) & Bioinformatics (dry lab), to join the Epitranscriptomics and RNA Dynamics group (PI: Eva Novoa), and co-supervised by Dr. Eduard Sabidó, Head of the Proteomics Unit to the study of the role of RNA modifications (the “epitranscriptome”) in neuronal RNAs using LC-MS/MS.

About the lab

The Epitranscriptomics and RNA Dynamics lab is focused on deciphering the role that RNA modifications play in a large variety of cellular contexts, including the development of novel technologies to map RNA modifications. In our lab, we are employing a combination of experimental (RNASeq, RIP-Seq polysome profiling, mouse/cell knockouts, Oxford Nanopore direct RNA sequencing) and computational techniques (NGS data analysis, algorithm development, machine learning), to unveil the secrets of three post-transcriptional regulatory layers: the epitranscriptome, RNA structure and ribosome specialization.

The CRG/UPF Proteomics Unit is focused on the characterization of proteins and RNA/DNA epigenetic modifications by mass spectrometry. In our lab, we are developing new analytical methods to identify and quantify modifications in (desoxi-)ribonucleosides, nitrogenous bases, and oligonucleotides in biomedical samples. These include new liquid chromatographic separations, new mass spectrometric acquisition strategies, and new data analysis pipelines.

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