PhD candidate in Neurosciences. Molecular interactions of guidance receptors acting in early cortical Development. (PRE260403042024)

Project title: Molecular interactions of guidance receptors acting in early cortical

Development

Area of knowledge: life sciences

Research project:

The development of a layered cortex requires tightly regulated cell migration events. These are controlled by context-dependent interactions of cell guidance receptors and their ligands, which occur between migrating cells and their environment. In this project, we focus on different receptors and their ligands, which together form combinatorial interactions that instruct the radial migration of cortical neurons in early cortical development. We will employ a multidisciplinary approach, encompassing cell-based assays, profiling experiments and design of structure-based mutants receptors to target specific protein complexes in vitro and in vivo using mouse models. This is a collaborative project with other labs from the University of Oxford and Bordeaux.

The candidate will join Daniel del Toro's lab, which is comprised of four PhD students, and is supported by one technician, along with rotating students. The lab is situated in the Biomedicine Department at the Faculty of Medicine (Campus Clinic) of the University of Barcelona.

A specific committee will evaluate the applications using the following criteria:

• Grade point average of the academic transcripts from the applicant's bachelor's or master's degree studies (or 1st and 2nd cycle): up to 5 points out of a total of 10.
• Curricular merits: up to 1 point out of a total of 10 in accordance with the specific criteria listed in Annex 1.
• Suitability for the tasks to be performed within the framework of the research project or research support position to which the successful candidate will be attached: up to 4 points out of a total of 10.

The specific committee will agree upon an award proposal and draw up a prioritized shortlist of candidates who have achieved a minimum of five points or declare the call for applications null and void if none of the applicants reach the minimum score.

The award proposal will be published in the UB's electronic office and must include the total scores of the candidates that have received a total of at least five points.

Application Process:

According to the specific requirements and selection criteria, the candidates are expected to provide at least the following documents:

•   Application form

• Full CV

•    BSc and MSc academic transcripts

• Doctoral program admission

The candidate proposed for hiring must accept the job offer within 5 working days from the date of notification of the selection.

Be aware that the starting date sets in this offer is an estimate date. The official starting date will depend on the time necessary for administration to prepare the labour contract and present the necessary documents for the selected candidate to be hired.

Priority will be given to people with disabilities (Law 89/2015 of June 2, reserve of quota 2% in favour of people with disabilities in companies of 50 or more people).