PhD position: Investigation of the mechanisms linking CAIX-related hypoxic tumor microenvironment and obesity to pancreatic cancer progression in relation to immune response

31 May 2023
Job Information

Organisation/Company

Biomedical Research Center, Slovak Academy of Sciences

Department

Department of Cancer Biology

Research Field

Medical sciences » Cancer research

Researcher Profile

First Stage Researcher (R1)

Country

Slovakia

Application Deadline

5 Jun 2023 - 23:59 (Europe/Bratislava)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

37,5

Offer Starting Date

1 Sep 2023

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Department of Cancer Biology of the Biomedical Research Center of the Slovak Academy of Sciences offers a four year doctoral study on the PhD thesis: "Investigation of the mechanisms linking CAIX-related hypoxic tumor microenvironment and obesity to pancreatic cancer progression in relation to immune response".

Supervisor: Mgr. Eliška Švastová, PhD.

Annotation:

The topic is focused on:

- the influence of CAIX expression and function on molecular cross-talk in tumor stroma among tumor cells, fibroblasts, adipocytes and immune cells with respect to its role in creating acidic and pro-invasive tumor microenvironment, and to investigate the impact of CAIX-related hypoxic/acidic TME on pro-tumorigenic environment in pancreatic cancer models

- the effect of CAIX expression and its inhibition on immune cell infiltration and macrophage differentiation in 3D spheroids

- the effect of adipokines on the progression of pancreatic tumor cells in relation to hypoxia and CAIX expression

Keywords: hypoxia, CAIX, pancreatic ductal adenocarcinoma, obesity, immune response

This PhD position is opened in collaboration with the Faculty of Medicine, Comenius University in Bratislava, in the study programme "oncology" and for school year 2023/2024.

The admission procedure is therefore managed by the Faculty of Medicine, Comenius University in Bratislava.For all instructions see here

Before submitting an application, pleasecontact the supervisor for further information and procedures (email: [email protected] ).

Requirements

Research Field

Medical sciences » Cancer research

Education Level

Master Degree or equivalent

Research Field

Biological sciences » Biology

Education Level

Master Degree or equivalent

Languages

ENGLISH

Level

Good

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

Biomedical Research Center, Slovak Academy of Sciences

Country

Slovakia

City

Bratislava

Postal Code

84505

Street

Dubravska cesta 9

Geofield

Where to apply

Website

https://www.fmed.uniba.sk/en/study/phd-study/admission-procedure/

Contact

City

Bratislava

Website

http://www.biomedcentrum.savba.sk/

Street

Dubravska cesta 9

Postal Code

84505

E-Mail

[email protected]

STATUS: EXPIRED