15 May 2024
Job Information
- Organisation/Company
Centre of Experimental Medicine of the Slovak Academy of Sciences- Research Field
Pharmacological sciences » Pharmacy- Researcher Profile
First Stage Researcher (R1)- Country
Slovakia- Application Deadline
31 May 2024 - 00:00 (Europe/Bratislava)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
37,5- Offer Starting Date
1 Sep 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The institute is looking for an excellent and highly motivated candidate for PhD in the field of Pharmacology
The thesis is focused on: Bee products are a frequent subject of preclinical and clinical studies. However, identification of the substances responsible for their therapeutic properties is lacking. The aim of this work will be to characterize the effect of selected peptides and polyphenolic extracts from bee products on the articular manifestations of rheumatoid arthritis (RA), but also on medically relevant extra-articular manifestations with the intention of optimizing conventional RA treatment. The pharmacological influence on the above RA symptoms will be evaluated using an adjuvant arthritis model in rats. In addition to biometric markers, markers of inflammation and oxidative stress will be determined in plasma and relevant tissues. Analysis of cardioprotective mechanisms and study of mitochondrial energetics will be performed. Finally, the efficacy of the most effective natural agent will be verified also in combination with methotrexate and upadacitinib.
Keywords: rheumatoid arthritis, adjuvant arthritis, bee products, bee pollen, propolis, honey, methotrexate and upadacitinib
Supervisor: Katarína Bauerová, PharmDr., DrSc.
Requirements
- Research Field
- Pharmacological sciences » Pharmacy
- Education Level
- Master Degree or equivalent
Skills/Qualifications
Theoretical background in pharmacological sciences
Experience in basic laboratory techniques, particularly with biochemical, physiological, and molecular analyses and in vitro techniques
- Languages
- ENGLISH
- Level
- Excellent
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Center of Experimental Medicine, Slovak Academy of Sciences
- Country
- Slovakia
- City
- Bratislava
- Postal Code
- 841014
- Street
- Dúbravská cesta 9
- Geofield
Where to apply
- Website
https://www.fpharm.uniba.sk/en/education/phd-study/admission-procedure/
Contact
- City
Bratislava- Website
https://cem.savba.sk/- Street
Dubravska cesta 9- Postal Code
84104
[email protected]- Phone
0232296064
STATUS: EXPIRED
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