PhD position - Designing stable chaperone platforms: from evolution to innovation

Updated: 2 months ago
Job Type: FullTime
Deadline: 15 Apr 2024

15 Feb 2024
Job Information
Organisation/Company

Pavol Jozef Šafárik University in Košice
Research Field

Physics » Biophysics
Chemistry » Biochemistry
Biological sciences » Biological engineering
Researcher Profile

First Stage Researcher (R1)
Country

Slovakia
Application Deadline

15 Apr 2024 - 00:00 (Europe/Bratislava)
Type of Contract

Temporary
Job Status

Full-time
Hours Per Week

37,5
Offer Starting Date

1 Sep 2024
Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Annotation of the dissertation topic: Join my research group in an exciting venture to develop new molecular platforms for detection and therapy, leveraging the potential of chaperone domains. This PhD project is at the forefront of molecular innovation, focusing on stabilizing these platforms for library construction and therapeutic applications. Your work will contribute to the development of novel molecular platforms with potential applications in detection and therapy, bridging the gap between basic molecular biology and applied biomedical research. As a PhD candidate, you will be actively involved in experimental design, data collection, analysis, and interpretation. You will have the opportunity to work with advanced technologies and contribute significantly to a rapidly evolving field. You will employ a range of cutting-edge techniques including evolutionary analysis, protein crystallization, and structural characterization using the synchrotron source.

Project goals:

1) Explore natural hyperstable chaperone domains and identify stabilization hotspots through comparative evolutionary analysis.

2) Investigate mesophilic and psychrophilic variants of chaperone domains from bacteria adapted to low-temperature environments.

3) Conduct functional analysis and crystallization of new chaperone domains and variants.


Requirements
Research Field
Biological sciences » Biological engineering
Education Level
Master Degree or equivalent

Research Field
Physics » Biophysics
Education Level
Master Degree or equivalent

Languages
ENGLISH
Level
Excellent

Additional Information
Work Location(s)
Number of offers available
1
Company/Institute
University PJ Safarik in Kosice, Slovakia
Country
Slovakia
Geofield


Where to apply
E-mail

[email protected]

Contact
City

Košice
Website

https://www.upjs.sk/
Street

Šrobárova 2
Postal Code

O41 80
E-Mail

[email protected]

STATUS: EXPIRED

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